Nucleotide-binding oligomerization domain-like receptors (NLRs), including NLRAs, NLRBs
(also known as NAIPs), NLRCs, and NLRPs, are a major subfamily of pattern recognition …

Epithelial–mesenchymal transition (EMT) is an important biological process contributing to
kidney fibrosis and chronic kidney disease. This process is characterized by decreased …

Renal fibrosis is the common feature of all progressive kidney diseases and exerts great
burden on public health worldwide. The maladaptive repair mechanism of tubular epithelial …

Aims Tubulointerstitial fibrosis, a frequent complication of chronic kidney disease (CKD) is a
major public health issue. Biochanin A (BCA), an isoflavone, has numerous …

Myofibroblasts are the principal effector cells driving fibrosis, and their accumulation in
tissues is a fundamental feature of fibrosis. Essential pathways have been identified as …

Aging-related diseases such as cancer, cardiovascular diseases, diabetes, and
neurodegenerative diseases are often accompanied by fibrosis. The NLRP3 inflammasome …

Background Necroptosis and pyroptosis, two types of proinflammatory programmed cell
death, were recently found to play important roles in spinal cord injury (SCI). Moreover …

Abstract Pentraxin 3 (PTX3) is a multifunctional molecule that mainly expressed in response
to proinflammatory stimuli under physiological and pathological conditions. It is produced in …

Background: Endoplasmic reticulum (ER) stress, a protective stress response of body and
play important role in maintain ER stability. Acute kidney injury (AKI) is a severe syndrome …

Antibody-mediated rejection (AMR) represents a major cause of allograft dysfunction and
results in allograft failure in solid organ transplantation. Cyclic helix B peptide (CHBP) is a …