T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

The gut microbiota is indispensable for maintaining host health by enhancing the host's
digestive capacity, safeguarding the intestinal epithelial barrier, and preventing pathogen …

In atherosclerosis, some regulatory T (Treg) cells become exTreg cells. We crossed
inducible Treg and exTreg cell lineage-tracker mice (FoxP3 eGFP− Cre-ERT2 ROSA26 CAG …

In addition to the roles of endothelial cells (ECs) in physiological processes, ECs actively
participate in both innate and adaptive immune responses. We previously reported that, in …

Regulatory T (Treg) cells constitute a dynamic population that is essential for controlling
immune responses in health and disease. Defects in Treg cell function and decreases in …

Autoimmune disease results from the immune response against self-antigens, while cancer
develops when the immune system does not respond to malignant cells. Thus, for years …

Regulatory T cells (Tregs) maintain immune equilibrium by suppressing immune responses
through various multistep contact dependent and independent mechanisms. Cellular …

Regulatory T cells (Tregs) express the lineage-defining transcription factor FoxP3 and play
crucial roles in self-tolerance and immune homeostasis. Thymic tTregs are selected based …

Bipolar disorder (BD) is a distinctly heterogeneous and multifactorial disorder with a high
individual and social burden. Immune pathway dysregulation is an important …

With the exception of an extremely small number of cases caused by single gene mutations,
most autoimmune diseases result from the complex interplay between environmental and …