Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression

J Heijman, N Voigt, S Nattel, D Dobrev - Circulation research, 2014 - Am Heart Assoc
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …

Atrial fibrillation from the pathologist's perspective

D Corradi - Cardiovascular pathology, 2014 - Elsevier
Atrial fibrillation (AF), the most common sustained cardiac arrhythmia encountered in clinical
practice, is associated with increased morbidity and mortality. Electrophysiologically, it is …

Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation

IE Christophersen, MS Olesen, B Liang… - European heart …, 2013 - academic.oup.com
Aims Genetic factors may be important in the development of atrial fibrillation (AF) in the
young. KCNA5 encodes the potassium channel α-subunit KV1. 5, which underlies the …

Pitx2, an Atrial Fibrillation Predisposition Gene, Directly Regulates Ion Transport and Intercalated Disc Genes

Y Tao, M Zhang, L Li, Y Bai, Y Zhou… - Circulation …, 2014 - Am Heart Assoc
Background—Pitx2 is the homeobox gene located in proximity to the human 4q25 familial
atrial fibrillation (AF) locus. When deleted in the mouse germline, Pitx2 haploinsufficiency …

PITX2‐dependent gene regulation in atrial fibrillation and rhythm control

F Syeda, P Kirchhof, L Fabritz - The Journal of Physiology, 2017 - Wiley Online Library
Atrial fibrillation (AF) is a common arrhythmia. Better prevention and treatment of AF are
needed to reduce AF‐associated morbidity and mortality. There are several major …

[HTML][HTML] Application of single-nucleotide polymorphism-related risk estimates in identification of increased genetic susceptibility to cardiovascular diseases: a literature …

S Fiatal, R Adany - Frontiers in public health, 2018 - frontiersin.org
Background Although largely preventable, cardiovascular diseases (CVDs) are the biggest
cause of death worldwide. Common complex cardiovascular disorders (eg, coronary heart …

Atrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis

B Laforest, W Dai, L Tyan, S Lazarevic… - The Journal of …, 2019 - Am Soc Clin Investig
Atrial fibrillation (AF), defined by disorganized atrial cardiac rhythm, is the most prevalent
cardiac arrhythmia worldwide. Recent genetic studies have highlighted a major heritable …

Multiple roles of Pitx2 in cardiac development and disease

D Franco, D Sedmera, E Lozano-Velasco - Journal of cardiovascular …, 2017 - mdpi.com
Cardiac development is a complex morphogenetic process initiated as bilateral cardiogenic
mesoderm is specified at both sides of the gastrulating embryo. Soon thereafter, these …

[HTML][HTML] Electrocardiogram (ECG) for the prediction of incident atrial fibrillation: an overview

Y Aizawa, H Watanabe, K Okumura - Journal of atrial fibrillation, 2017 - ncbi.nlm.nih.gov
Electrocardiograms (ECGs) have been employed to medically evaluate participants in
population-based studies, and ECG-derived predictors have been reported for incident atrial …

South Asian ethnicity is associated with a lower prevalence of atrial fibrillation despite greater prevalence of established risk factors: a population-based study in …

RG Gillott, K Willan, K Kain, UM Sivananthan… - Ep …, 2017 - academic.oup.com
Aims Previous studies indicate that South Asians (SAs) may have a reduced risk of
developing atrial fibrillation (AF) despite having a higher prevalence of traditional …