Molecular pathogenesis of membranous nephropathy

P Ronco, H Debiec - Annual Review of Pathology: Mechanisms …, 2020 - annualreviews.org
Membranous nephropathy is a noninflammatory autoimmune disease of the kidney
glomerulus, characterized by the formation of immune deposits, complement-mediated …

A novel insight into the role of PLA2R and THSD7A in membranous nephropathy

P Zhang, W Huang, Q Zheng, J Tang… - Journal of …, 2021 - Wiley Online Library
Membranous nephropathy (MN) is an organ‐restricted autoimmune disease mainly caused
by circulating autoantibodies against podocyte antigens, including the M‐type …

The potential role of regulatory B cells in idiopathic membranous nephropathy

Z Dong, Z Liu, H Dai, W Liu, Z Feng… - Journal of …, 2020 - Wiley Online Library
Regulatory B cells (Breg) are widely regarded as immunomodulatory cells which play an
immunosuppressive role. Breg inhibits pathological autoimmune response by secreting …

Advances of the experimental models of idiopathic membranous nephropathy

HX Jiang, Z Feng, ZB Zhu, CH Xia… - Molecular …, 2020 - spandidos-publications.com
Idiopathic membranous nephropathy (IMN) is one of the main types of chronic kidney
disease in adults and one of the most common causes of end‑stage renal disease. In recent …

Association of 10 Polymorphisms in PLA2R1 and HLA DQA1 Genes with Primary Membranous Nephropathy Risk: A Meta-Analysis and a Meta-Regression

T Dhaouadi, A Riahi, TB Abdallah… - Biomarker …, 2024 - journals.sagepub.com
Background: Although, several studies have assessed the association of the phospholipase
A2 receptor (PLA2R) and HLA-DQA1 SNPs with primary membranous nephropathy (PMN) …

Mutational analysis on predicting the impact of high-risk SNPs in human secretary phospholipase A2 receptor (PLA2R1)

Z Khalid, O Almaghrabi - Scientific reports, 2020 - nature.com
PLA2R1 is a transmembrane glycoprotein that acts as an endogenous ligand which
stimulates the processes including cell proliferation and cell migration. The SNPs in PLA2R1 …

Forward Selection of Relevant Factors by Means of MDR-EFE Method

A Bulinski - Mathematics, 2024 - mdpi.com
The suboptimal procedure under consideration, based on the MDR-EFE algorithm, provides
sequential selection of relevant (in a sense) factors affecting the studied, in general, non …

Associations between m-type phospholipase A2 receptor, human leukocyte antigen gene polymorphisms and idiopathic membranous nephropathy

X Liu, W Xu, C Yu, M Wang, R Liu, R Xie - Bioengineered, 2021 - Taylor & Francis
Primary membranous nephropathy, also known as idiopathic membranous nephropathy, is
an autoimmune disease. As an autoimmune disease, genetic factors are essential in the …

The association between variants in PLA2R and HLA-DQA1 and renal outcomes in patients with primary membranous nephropathy in Western China

S Fan, Q Wang, AY Wang, P Zhang, X Zhong… - BMC Medical …, 2021 - Springer
Abstract Background Both Genome-wide associations and our previous study have shown
that single nucleotide polymorphisms (SNPs) of M-type phospholipase A2 receptor (PLA2R) …

[PDF][PDF] 氯沙坦钾治疗特发性膜性肾病对血清抗PLA2R 抗体的影响

方纪林, 蒋红利, 李向东, 李毅, 赵明… - Progress in Modern …, 2020 - biomed.cnjournals.com
摘要目的: 探讨氯沙坦钾治疗特发性膜性肾病对血清抗磷脂酶A2 受体(Phospho lipase A2
receptor, PLA2R) 抗体的影响. 方法: 2014 年8 月到2018 年8 月选择在西安交通大学医学院 …