Alzheimer's disease (AD) involves the progressive degeneration of neurons critical for
learning and memory. In addition, patients with AD typically exhibit impaired olfaction …

Potassium ions can cross both the outer and inner mitochondrial membranes by means of
multiple routes. A few potassium-permeable ion channels exist in the outer membrane, while …

The ability of novel mitochondrial uncoupler prodrug of 2, 4‐dinitrophenol (DNP), MP201, to
prevent neuronal damage and preserve visual function in an experimental autoimmune …

Amyotrophic lateral sclerosis (ALS) is a fatal, neurodegenerative disease that is
characterized by the selective degeneration of upper motor neurons and lower spinal motor …

Ion channels are integral membrane proteins that allow passive diffusion of ions across
membranes. In neurons and in other excitable cells, the harmonious coordination between …

The current paradigm in the amyloid hypothesis brands small β-amyloid (Aβ) oligomers as
the toxic species in Alzheimer's disease (AD). These oligomers are fibril-like; contain β-sheet …

In the recent past, a plethora of drugs have been approved for the treatment of multiple
sclerosis (MS). These therapeutics are mainly confined to immunomodulatory or …

Destabilization of cellular ionic homeostasis by toxic β-amyloid (Aβ) channels/barrels, which
is a pathogenic mechanism for Alzheimer's disease (AD), is inhibited by a novel anti-AD …

Alzheimer's disease (AD) is characterized by progressive cognitive impairment and by
extensive neuronal loss associated with extracellular amyloid β-peptide (Aβ) plaques and …

Pharmacological modulation of ATP-sensitive potassium channels has become a promising
new therapeutic approach for the treatment of neurodegenerative diseases due to their role …