The current paradigm in the amyloid hypothesis brands small β-amyloid (Aβ) oligomers as
the toxic species in Alzheimer's disease (AD). These oligomers are fibril-like; contain β-sheet …

In the recent past, a plethora of drugs have been approved for the treatment of multiple
sclerosis (MS). These therapeutics are mainly confined to immunomodulatory or …

Destabilization of cellular ionic homeostasis by toxic β-amyloid (Aβ) channels/barrels, which
is a pathogenic mechanism for Alzheimer's disease (AD), is inhibited by a novel anti-AD …

Alzheimer's disease (AD) is characterized by progressive cognitive impairment and by
extensive neuronal loss associated with extracellular amyloid β-peptide (Aβ) plaques and …

Pharmacological modulation of ATP-sensitive potassium channels has become a promising
new therapeutic approach for the treatment of neurodegenerative diseases due to their role …

Nicorandil, an ATP-sensitive potassium (K ATP) channel opener, is known to have protective
effects on ischemic injury in heart and brain. One of the most important protective …

The neurodegenerative diseases described in this volume, as well as many
nonneurodegenerative diseases, are characterized by deposits known as amyloid. Amyloid …

Reductions in cerebral metabolism sufficient to impair cognition in normal individuals also
occur in Alzheimer's disease (AD). FDG PET studies have shown that decreased glucose …

Cerebrovascular and cardiovascular diseases are stated as important risk factors of vascular
dementia (VaD) and other cognitive disorders. In the central nervous system, melatonin (MT …

In addition to coupling cell metabolism and excitability, ATP-sensitive potassium channels (K
ATP) are involved in neural function and plasticity. Moreover, alterations in K ATP activity …