Effects of nicorandil on neurobehavioral function, BBB integrity, edema and stereological parameters of the brain in the sub-acute phase of stroke in a rat model
M Owjfard, MR Bigdeli, A Safari, MR Namavar - Journal of biosciences, 2020 - Springer
Blood–brain barrier (BBB) disruption, inflammation, and cell death are the pathogenic
mechanisms of cerebral ischemia/reperfusion (I/R) injury. Nicorandil protects ischemic injury …
mechanisms of cerebral ischemia/reperfusion (I/R) injury. Nicorandil protects ischemic injury …
Oral administration of the KATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis
N Virgili, JF Espinosa-Parrilla, P Mancera… - Journal of …, 2011 - Springer
Abstract Background Multiple Sclerosis (MS) is an acquired inflammatory demyelinating
disorder of the central nervous system (CNS) and is the leading cause of nontraumatic …
disorder of the central nervous system (CNS) and is the leading cause of nontraumatic …
Potential Alzheimer's early biomarkers in a transgenic rat model and benefits of diazoxide/dibenzoylmethane co-treatment on spatial memory and AD-pathology
Alzheimer's disease (AD) is the major form of dementia prevalent in older adults and with a
high incidence in females. Identification of early biomarkers is essential for preventive …
high incidence in females. Identification of early biomarkers is essential for preventive …
Identification of potential repurposable drugs in alzheimer's disease exploiting a bioinformatics analysis
Alzheimer's disease (AD) is a neurologic disorder causing brain atrophy and the death of
brain cells. It is a progressive condition marked by cognitive and behavioral impairment that …
brain cells. It is a progressive condition marked by cognitive and behavioral impairment that …
Ion Channels and Ionotropic Receptors in Astrocytes: Physiological Functions and Alterations in Alzheimer's Disease and Glioblastoma
The human brain is composed of nearly one hundred billion neurons and an equal number
of glial cells, including macroglia, ie, astrocytes and oligodendrocytes, and microglia, the …
of glial cells, including macroglia, ie, astrocytes and oligodendrocytes, and microglia, the …
Aberrant expression of the pore-forming KATP channel subunit Kir6. 2 in hippocampal reactive astrocytes in the 3xTg-AD mouse model and human Alzheimer's …
CM Griffith, MX Xie, WY Qiu, AA Sharp, C Ma, A Pan… - Neuroscience, 2016 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by beta-
amyloid (Aβ) deposition, neurofibrillary tangles and cognitive decline. Recent …
amyloid (Aβ) deposition, neurofibrillary tangles and cognitive decline. Recent …
Involvement of GABAergic interneuron dysfunction and neuronal network hyperexcitability in Alzheimer's disease: Amelioration by metabolic switching
MP Mattson - International Review of Neurobiology, 2020 - Elsevier
Evidence accumulated over the past three decades suggests that the neurons that
degenerate in Alzheimer's disease (AD) suffer metabolic compromise, hyperexcitability and …
degenerate in Alzheimer's disease (AD) suffer metabolic compromise, hyperexcitability and …
[HTML][HTML] Kir6. 2 is essential to maintain neurite features by modulating PM20D1-reduced mitochondrial ATP generation
N Song, Y Fang, H Zhu, J Liu, S Jiang, S Sun, R Xu… - Redox Biology, 2021 - Elsevier
Abstract Kir6. 2, a pore-forming subunit of the ATP-sensitive potassium (KATP) channels,
regulates the functions of metabolically active tissues and acts as an ideal therapeutic target …
regulates the functions of metabolically active tissues and acts as an ideal therapeutic target …
[HTML][HTML] Alzheimer's disease THErapy with NEuroaid (ATHENE): A randomized double-blind delayed-start trial
Objectives Preclinical and clinical studies indicate a role for MLC901 (NeuroAiD II) in
Alzheimer's disease (AD). The primary aim was to investigate its safety as add-on therapy to …
Alzheimer's disease (AD). The primary aim was to investigate its safety as add-on therapy to …
[HTML][HTML] Targeting Microglial KATP Channels to Treat Neurodegenerative Diseases: A Mitochondrial Issue
MJ Rodríguez, M Martínez-Moreno, FJ Ortega… - … Medicine and Cellular …, 2013 - hindawi.com
Neurodegeneration is a complex process involving different cell types and
neurotransmitters. A common characteristic of neurodegenerative disorders is the …
neurotransmitters. A common characteristic of neurodegenerative disorders is the …