[HTML][HTML] Role of mitochondrial potassium channels in ageing
L Flori, J Spezzini, V Calderone, L Testai - Mitochondrion, 2024 - Elsevier
Ageing is described as an inevitable decline in body functions over time and an increase in
susceptibility to age-related diseases. Therefore, the increase of life expectancy is also …
susceptibility to age-related diseases. Therefore, the increase of life expectancy is also …
Neuroprotective effect of nicorandil through inhibition of apoptosis by the PI3K/Akt1 pathway in a mouse model of deep hypothermic low flow
D Yu, C Fan, W Zhang, Z Wen, L Hu, L Yang… - Journal of the …, 2015 - Elsevier
Objective Nicorandil exerts a protective effect on ischemia–reperfusion (I/R) injury in the
brain and kidney through anti-apoptotic mechanisms. However, the mechanism by which …
brain and kidney through anti-apoptotic mechanisms. However, the mechanism by which …
Age-related impairment of cerebral blood flow response to KATP channel opener in Alzheimer's disease mice with presenilin-1 mutation
Local cerebral blood flow (CBF) responses to neuronal activity are essential for cognition
and impaired CBF responses occur in Alzheimer's disease (AD). In this study, regional CBF …
and impaired CBF responses occur in Alzheimer's disease (AD). In this study, regional CBF …
DNA immunization with HBsAg-based particles expressing a B cell epitope of amyloid β-peptide attenuates disease progression and prolongs survival in a mouse …
PB Olkhanud, M Mughal, K Ayukawa, E Malchinkhuu… - Vaccine, 2012 - Elsevier
Alzheimer's disease (AD) is an incurable and progressive neurodegenerative senile
disorder associated with the brain accumulation of Aβ plaques. Although vaccines that …
disorder associated with the brain accumulation of Aβ plaques. Although vaccines that …
[HTML][HTML] Microfluidic Formulation of Diazoxide-Loaded Solid Lipid Nanoparticles as a Novel Approach for Friedreich's Ataxia Treatment
I Arduino, A Santoro, S De Santis, RM Iacobazzi… - Journal of Drug Delivery …, 2024 - Elsevier
Friedreich ataxia (FRDA) is a hereditary autosomal recessive disorder characterized by
frataxin deficiency, impacting mitochondrial function and causing oxidative damage …
frataxin deficiency, impacting mitochondrial function and causing oxidative damage …
Current drug targets for modulating Alzheimer's amyloid precursor protein: role of specific micro-RNA species
Alzheimer's disease (AD) is the most common form of dementia in the United States and is
increasing in prevalence every year throughout the world. Recent clinical trial failures …
increasing in prevalence every year throughout the world. Recent clinical trial failures …
Bridging the pathophysiology of Alzheimer's disease with vascular pathology: the feed-back, the feed-forward, and oxidative stress
MC Polidori, L Pientka - Journal of Alzheimer's Disease, 2012 - content.iospress.com
Alzheimer's disease (AD) is slowly but steadily undergoing a profound reshaping of the
definition and approach caused by the frustrating gap between poorly controlled AD …
definition and approach caused by the frustrating gap between poorly controlled AD …
In vivo and in vitro attenuation of naloxone-precipitated experimental opioid withdrawal syndrome by insulin and selective KATP channel modulator
Rationale Opiate exposure for longer duration develops state of dependence in humans and
animals, which is revealed by signs and symptoms of withdrawal precipitated by opioid …
animals, which is revealed by signs and symptoms of withdrawal precipitated by opioid …
[图书][B] Sculptor and Destroyer: Tales of Glutamatethe Brain's Most Important Neurotransmitter
MP Mattson - 2023 - books.google.com
The fascinating story of glutamate, the neurotransmitter that controls the structure and
function of the brain in health and neurological disorders. Sculptor and Destroyer tells the …
function of the brain in health and neurological disorders. Sculptor and Destroyer tells the …
Pathophysiological role of mitochondrial potassium channels and their modulation by drugs
V Citi, V Calderone, A Martelli… - Current medicinal …, 2018 - ingentaconnect.com
Background: Mitochondria play a central role in ATP-generating processes. Indeed, in
mammalian tissues, up to 90% of ATP is generated by mitochondria through the process of …
mammalian tissues, up to 90% of ATP is generated by mitochondria through the process of …