Acute exposure of the mediobasal hypothalamus to amyloid-β 25-35 perturbs hepatic glucose metabolism
I Arrieta-Cruz, CM Knight… - Journal of Alzheimer's …, 2015 - content.iospress.com
Patients with Alzheimer's disease (AD) have a higher risk for developing insulin resistance
and diabetes. Amyloid plaques, a hallmark of AD, are composed of amyloid-β (Aβ). Because …
and diabetes. Amyloid plaques, a hallmark of AD, are composed of amyloid-β (Aβ). Because …
Amyloid peptide channels
R Azimov, BL Kagan - Electrophysiology of Unconventional Channels and …, 2015 - Springer
Amyloid peptides and proteins appear to play a pathophysiologic role in amyloid diseases.
Many amyloid peptides have been found to form ion channels under physiologic conditions …
Many amyloid peptides have been found to form ion channels under physiologic conditions …
Diazoxide/dibenozylmethane treatment mitigates spatial memory deficits and pathology and up regulates protective genes in an Alzheimer's transgenic rat model
Alzheimers disease (AD) is a multifactorial disease for which therapeutic efficacy should
benefit from a multi-target approach. Thus, we evaluated a combined chronic treatment with …
benefit from a multi-target approach. Thus, we evaluated a combined chronic treatment with …
Redox-active Cu (II)–Aβ causes substantial changes in axonal integrity in cultured cortical neurons in an oxidative-stress dependent manner
C Howells, K Saar, E Eaton, S Ray, P Palumaa… - Experimental …, 2012 - Elsevier
BACKGROUND: The beta-amyloid (Aβ) peptide comprises the amyloid plaques that
characterise Alzheimer's disease (AD), and is thought to significantly contribute towards …
characterise Alzheimer's disease (AD), and is thought to significantly contribute towards …
Levosimendan ameliorates the scopolamine induced cognitive impairment via modulating pCREB/BDNF expression, cholinergic neurotransmission and …
AS Kolusu, GS Ganesh, M Nagabhairava… - 2023 - researchsquare.com
Levosimendan, an inotropic drug that potentiates ATP-dependent K+ channel and sensitise
troponin-C for calcium. It has positive effects in neurodegenerative diseases like Parkinson's …
troponin-C for calcium. It has positive effects in neurodegenerative diseases like Parkinson's …
Diazoxide enhances excitotoxicity-induced neurogenesis and attenuates neurodegeneration in the rat non-neurogenic hippocampus
M Martínez-Moreno, M Batlle, FJ Ortega… - Neuroscience, 2016 - Elsevier
Diazoxide, a well-known mitochondrial K ATP channel opener with neuroprotective effects,
has been proposed for the effective and safe treatment of neuroinflammation. To test …
has been proposed for the effective and safe treatment of neuroinflammation. To test …
Potential therapeutic strategies to prevent the progression of alzheimer to disease states
E Aso, I Ferrer - Understanding Alzheimer's Disease, 2013 - books.google.com
Alzheimer is an age-dependent neurodegenerative process distinct from normal aging and
characterized morphologically by the presence of senile plaques and neurofibrillary tangles …
characterized morphologically by the presence of senile plaques and neurofibrillary tangles …
ATP 敏感性钾通道开放剂神经保护作用的研究进展
曹云鹏， 孔晶晶 - 中华神经医学杂志, 2013 - cqvip.com
Noma 于1983 年首先利用膜片钳技术在豚鼠的心肌细胞上发现三磷酸腺苷(ATP)
敏感性钾通道(KATP). 随后的研究证实, 此通道也存在于众多可兴奋细胞以及细胞器如线粒体上 …
敏感性钾通道(KATP). 随后的研究证实, 此通道也存在于众多可兴奋细胞以及细胞器如线粒体上 …
[PDF][PDF] Mitochondria and fatty acid homeostasis in the aging nervous system
JR Lee - Ph. D. Thesis, 2019 - prism.ucalgary.ca
Impairments of learning and memory are among the most salient outcomes of the natural
aging process. Particularly among humans who have experienced dramatic increases in …
aging process. Particularly among humans who have experienced dramatic increases in …
Sculptor and Destroyer
MP Mattson - Addiction - direct.mit.edu
Alzheimer's disease and Parkinson's disease are the two most common neurodegenerative
brain disorders. Most cases of these degenerative brain diseases manifest in people who …
brain disorders. Most cases of these degenerative brain diseases manifest in people who …