Multi-compound and drug-combination pharmacokinetic research on Chinese herbal medicines

C Li, W Jia, J Yang, C Cheng, OE Olaleye - Acta Pharmacologica Sinica, 2022 - nature.com
Traditional medicine has provided a basis for health care and disease treatment to Chinese
people for millennia, and herbal medicines are regulated as drug products in China …

[HTML][HTML] A comprehensive review of integrative pharmacology-based investigation: A paradigm shift in traditional Chinese medicine

H Xu, Y Zhang, P Wang, J Zhang, H Chen… - … Pharmaceutica Sinica B, 2021 - Elsevier
Over the past decade, traditional Chinese medicine (TCM) has widely embraced systems
biology and its various data integration approaches to promote its modernization. Thus …

[PDF][PDF] 中药质量标志物(Q-Marker): 中药产品质量控制的新概念

刘昌孝, 陈士林, 肖小河, 张铁军, 侯文彬, 廖茂梁 - 中草药, 2016 - tiprpress.com
为促进中医药产业健康发展, 完善质量标准体系, 健全以《 中国药典》 为核心的国家药品标准体系
, 提升中药及产品质量标准, 在研究现有质量评价与控制方法及存在问题的基础上 …

Absorption and disposition of ginsenosides after oral administration of Panax notoginseng extract to rats

H Liu, J Yang, F Du, X Gao, X Ma, Y Huang, F Xu… - Drug Metabolism and …, 2009 - ASPET
Panax notoginseng (Sanqi) is a cardiovascular herb containing ginsenosides that are
believed to be responsible for the therapeutic effects of Sanqi. The aim of this study was to …

A new concept on quality marker for quality assessment and process control of Chinese medicines

C Liu, Y Cheng, D Guo, T Zhang, Y Li, W Hou… - Chinese Herbal …, 2017 - Elsevier
Chinese medicine (CM) is the most typical conventional therapy compared with any other
traditional or alternative medicine systems. The active components of CMs are either primary …

Understanding the binding between Rosmarinic acid and serum albumin: In vitro and in silico insight

A Shamsi, A Ahmed, MS Khan, M Al Shahwan… - Journal of Molecular …, 2020 - Elsevier
Rosmarinic acid (RA) is a natural product that is increasingly being used in food industries
and cosmetic industries. Drug pharmacokinetics is affected upon binding with protein, thus …

Absorption, disposition, and pharmacokinetics of saponins from Chinese medicinal herbs: what do we know and what do we need to know more?

K Yu, F Chen, C Li - Current drug metabolism, 2012 - ingentaconnect.com
Saponins are a group of amphiphilic glycosides containing one or more sugar chains linked
to a nonpolar triterpene or steroid aglycone skeleton, which are believed to be responsible …

A strategy for the identification of combinatorial bioactive compounds contributing to the holistic effect of herbal medicines

F Long, H Yang, Y Xu, H Hao, P Li - Scientific reports, 2015 - nature.com
It has been well claimed that herbal medicines (HMs) elicit effects via a multi-compounds
and multi-targets synergistic mode. However, it lacks appropriate strategies to uncover the …

Bioactive equivalence of combinatorial components identified in screening of an herbal medicine

P Liu, H Yang, F Long, HP Hao, X Xu, Y Liu… - Pharmaceutical …, 2014 - Springer
Purpose To identify bioactive equivalent combinatorial components (BECCs) in herbal
medicines. The exact composition of effective components in herbal medicines is often …

Mechanism of platelet activation and potential therapeutic effects of natural drugs

Y Zhou, D Zhang, P Tan, B Xian, H Jiang, Q Wu… - Phytomedicine, 2023 - Elsevier
Background Cardiovascular disease is one of the most concerning chronic diseases in the
world. Many studies have shown that platelet overactivation is a very important factor in the …