Biosystem‐inspired engineering of nanozymes for biomedical applications

L Zhang, H Wang, X Qu - Advanced Materials, 2024 - Wiley Online Library
Nanozymes with intrinsic enzyme‐mimicking activities have shown great potential to
become surrogates of natural enzymes in many fields by virtue of their advantages of high …

Bioactive Iridium Nanoclusters with Glutathione Depletion Ability for Enhanced Sonodynamic‐Triggered Ferroptosis‐Like Cancer Cell Death

T Nie, W Zou, Z Meng, L Wang, T Ying, X Cai… - Advanced …, 2022 - Wiley Online Library
Ferroptosis is a regulated form of necrotic cell death that involves the accumulation of lipid
peroxide (LPO) species in an iron‐and reactive oxygen species (ROS)‐dependent manner …

Nanozyme-based strategies for efficient theranostics of brain diseases

R Xu, S Zhang, P Wang, R Zhang, P Lin, Y Wang… - Coordination Chemistry …, 2024 - Elsevier
Oxidative stress emerges as a critical mechanism underlying the development and
progression of various brain diseases, arising from either increased generation of reactive …

[HTML][HTML] Pathological BBB crossing melanin-like nanoparticles as metal-ion chelators and neuroinflammation regulators against Alzheimer's disease

Q Huang, C Jiang, X Xia, Y Wang, C Yan, X Wang… - Research, 2023 - spj.science.org
Inflammatory responses, manifested in excessive oxidative stress and microglia
overactivation, together with metal ion-triggered amyloid-beta (Aβ) deposition, are critical …

Redox homeostasis strategy for inflammatory macrophage reprogramming in rheumatoid arthritis based on ceria oxide nanozyme-complexed biopolymeric micelles

F Zhou, M Li, M Chen, M Chen, X Chen, Z Luo, K Cai… - ACS …, 2023 - ACS Publications
The synovial tissues under rheumatoid arthritis conditions are usually infiltrated by
inflammatory cells, particularly M1 macrophages with aberrant redox homeostasis, which …

Clustered cobalt nanodots initiate ferroptosis by upregulating heme oxygenase 1 for radiotherapy sensitization

J Zhao, Y Chen, T Xiong, S Han, C Li, Y He, Y He… - Small, 2023 - Wiley Online Library
High cobalt (Co) levels in tumors are associated with good clinical prognosis. An anticancer
regimen that increases intratumoral Co through targeted nanomaterial delivery is proposed …

Post-remedial oxygen supply: a new perspective on photodynamic therapy to suppress tumor metastasis

C Qiao, Z Yang, X Liu, R Zhang, Y Xia, L Wang… - Nano Letters, 2022 - ACS Publications
Photodynamic therapy (PDT) holds great promise in tumor therapy due to high safety,
efficacy, and specificity. However, the risk of increased metastasis in hypoxic tumors after …

Stabilized and controlled release of radicals within copper formate-based nanozymes for biosensing

Y Zhou, X Chen, S Zhan, Q Wang, F Deng… - … Applied Materials & …, 2023 - ACS Publications
Fenton-like radical processes are widely utilized to explain catalytic mechanisms of
peroxidase-like nanozymes, which exhibit remarkable catalytic activity, cost-effectiveness …

Polyphenol-assisted albumin-based biomineralization nanocarriers with NIR-II-targeted photothermal performance towards broad-spectrum radical scavenging

Y Zhao, J Wang, S Chen, Z Wei, Y Xie… - Journal of Materials …, 2023 - pubs.rsc.org
The oxidative stress is a state of imbalance in the body's oxidative balance, which can cause
or worsen many diseases. Several studies have focused on the direct scavenging of free …

LYC loaded ferritin nanoparticles for intracerebral delivery and the attenuation of neurodegeneration in D-gal-induced mice

X Xia, H Li, X Xu, C Wu, Z Wang, J Yi, G Zhao… - Biomaterials Advances, 2023 - Elsevier
Recombinant human H-ferritin nanocage (rHuHF) loaded with natural antioxidative
lycopene molecules (LYC) was successfully constructed for the first time, aiming to enrich …