The phenotypic and regulatory variability of drug transporter (DT) are vital for the
understanding of drug responses, drug-drug interactions, multidrug resistances, and so on …

Abstract Background and Objective An ever-growing body of evidence supports the impact
of cytokine modulation on the patient's phenotypic drug response. The aim of this systematic …

The past few years have ushered in a wealth of new information on transporter biology,
ranging from the publication of new crystal structures of the human glucose transporters …

The organic anion transporters (OATs) and organic anion–transporting polypeptides
(OATPs) belong to the solute carrier (SLC) transporter superfamily and play important roles …

Typically, therapeutic proteins (TPs) have a low risk for eliciting meaningful drug interactions
(DIs). However, there are select instances where TP drug interactions (TP‐DIs) of clinical …

Coproporphyrin I (CPI) is an endogenous biomarker of organic anion transporting
polypeptide 1B transporter (OATP1B). CPI plasma baseline was reported to increase with …

How organs sense circulating metabolites is a key question. Here, we show that the
multispecific organic anion transporters of drugs, OAT1 (SLC22A6 or NKT) and OAT3 …

Paeonol is a naturally occurring phenolic agent that attenuates neurotoxicity in
neurodegenerative diseases. We aimed to investigate the antioxidant and protective effects …

This article reports on an American Society of Pharmacology and Therapeutics, Division of
Drug Metabolism and Disposition symposium held at Experimental Biology on April 2, 2022 …

The effect of membrane transporters on drug disposition, efficacy and safety is now well
recognized. Since the initial publication from the International Transporter Consortium …