[HTML][HTML] Expression and functional contribution of different organic cation transporters to the cellular uptake of doxorubicin into human breast cancer and cardiac tissue

M Otter, S Csader, M Keiser, S Oswald - International journal of molecular …, 2021 - mdpi.com
Doxorubicin is a frequently used anticancer drug to treat many types of tumors, such as
breast cancer or bronchial carcinoma. The clinical use of doxorubicin is limited by its poorly …

[HTML][HTML] Nonalcoholic fatty liver disease (NAFLD) and hepatic cytochrome P450 (CYP) enzymes

R Jamwal, BJ Barlock - Pharmaceuticals, 2020 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive fat in the liver. An
international consensus panel has recently proposed to rename the disease to metabolic …

[HTML][HTML] The transporter-mediated cellular uptake and efflux of pharmaceutical drugs and biotechnology products: how and why phospholipid bilayer transport is …

DB Kell - Molecules, 2021 - mdpi.com
Over the years, my colleagues and I have come to realise that the likelihood of
pharmaceutical drugs being able to diffuse through whatever unhindered phospholipid …

[HTML][HTML] The Impact of Inflammation on the In Vivo Activity of the Renal Transporters OAT1/3 in Pregnant Women Diagnosed with Acute Pyelonephritis

JRL Benzi, PPS Melli, G Duarte, JD Unadkat… - Pharmaceutics, 2023 - mdpi.com
Inflammation can regulate hepatic drug metabolism enzymes and transporters. The impact
of inflammation on renal drug transporters remains to be elucidated. We aimed to quantify …

Comprehensive evaluation of the utility of 20 endogenous molecules as biomarkers of OATP1B inhibition compared with rosuvastatin and coproporphyrin I

S Barnett, K Ogungbenro, K Menochet, H Shen… - … of Pharmacology and …, 2019 - ASPET
Endogenous biomarkers can be clinically relevant tools for the assessment of transporter
function in vivo and corresponding drug-drug interactions (DDIs). The aim of this study was …

Quantitative proteomic map of enzymes and transporters in the human kidney: stepping closer to mechanistic kidney models to define local kinetics

ZM Al‐Majdoub, D Scotcher, B Achour… - Clinical …, 2021 - Wiley Online Library
The applications of translational modeling of local drug concentrations in various organs
had a sharp increase over the last decade. These are part of the model‐informed drug …

Protein abundance of hepatic drug transporters in patients with different forms of liver damage

M Drozdzik, S Szelag‐Pieniek, M Post… - Clinical …, 2020 - Wiley Online Library
Hepatocellular transporter levels were quantified using quantitative reverse transcription
polymerase chain reaction and liquid chromatography–tandem mass spectrometry methods …

[HTML][HTML] Developmental patterns in human blood–brain barrier and blood–cerebrospinal fluid barrier ABC drug transporter expression

LFM Verscheijden, AC Van Hattem, J Pertijs… - Histochemistry and Cell …, 2020 - Springer
When drugs exert their effects in the brain, linear extrapolation of doses from adults could be
harmful for children as the blood–brain barrier (BBB) and blood–CSF barrier (BCSFB) …

The regional-specific relative and absolute expression of gut transporters in adult caucasians: a meta-analysis

MD Harwood, M Zhang, SM Pathak, S Neuhoff - Drug Metabolism and …, 2019 - ASPET
The aim of this study was to derive region-specific transporter expression data suitable for in
vitro-to-in vivo extrapolation (IVIVE) within a physiologically based pharmacokinetic (PBPK) …

Physiologically‐based pharmacokinetic modelling of creatinine‐drug interactions in the chronic kidney disease population

H Takita, D Scotcher, R Chinnadurai… - CPT …, 2020 - Wiley Online Library
Elevated serum creatinine (SCr) caused by the inhibition of renal transporter (s) may be
misinterpreted as kidney injury. The interpretation is more complicated in patients with …