Doxorubicin is a frequently used anticancer drug to treat many types of tumors, such as
breast cancer or bronchial carcinoma. The clinical use of doxorubicin is limited by its poorly …

Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive fat in the liver. An
international consensus panel has recently proposed to rename the disease to metabolic …

Over the years, my colleagues and I have come to realise that the likelihood of
pharmaceutical drugs being able to diffuse through whatever unhindered phospholipid …

Inflammation can regulate hepatic drug metabolism enzymes and transporters. The impact
of inflammation on renal drug transporters remains to be elucidated. We aimed to quantify …

Endogenous biomarkers can be clinically relevant tools for the assessment of transporter
function in vivo and corresponding drug-drug interactions (DDIs). The aim of this study was …

The applications of translational modeling of local drug concentrations in various organs
had a sharp increase over the last decade. These are part of the model‐informed drug …

Hepatocellular transporter levels were quantified using quantitative reverse transcription
polymerase chain reaction and liquid chromatography–tandem mass spectrometry methods …

When drugs exert their effects in the brain, linear extrapolation of doses from adults could be
harmful for children as the blood–brain barrier (BBB) and blood–CSF barrier (BCSFB) …

The aim of this study was to derive region-specific transporter expression data suitable for in
vitro-to-in vivo extrapolation (IVIVE) within a physiologically based pharmacokinetic (PBPK) …

Elevated serum creatinine (SCr) caused by the inhibition of renal transporter (s) may be
misinterpreted as kidney injury. The interpretation is more complicated in patients with …