Introduction: ATP-binding cassette (ABC) transporters, especially P-glycoprotein (P-gp), and
various metabolic enzymes, in particular, CYP3A, expressed in the small intestine …

Dose recommendations for lamivudine or emtricitabine in children with HIV and chronic
kidney disease (CKD) are absent or not supported by clinical data. Physiologically based …

Highlights•Growth and development of the human body affect drug disposition and
efficacy.•Age-related changes are difficult to study, due to ethical and practical challenges.• …

Introduction: Precision drug therapy requires accounting for pertinent factors in
pharmacokinetic (PK) inter-individual variability (ie., pharmacogenetics, diseases …

Aims Rheumatoid arthritis (RA) is a long term autoimmune inflammatory disease
characterized by high autoantibody production and cytokine release, especially IL-6 and …

Introduction: Membrane transporters of the SLC and ABC families are abundantly expressed
in the liver, where they control the transfer of drugs/drug metabolites across the sinusoidal …

Alterations in hepatic transporters have been identified in precirrhotic chronic liver diseases
(CLDs) that result in pharmacokinetic variations causing adverse drug reactions (ADRs) …

The disposition of a drug is driven by various processes, such as drug metabolism, drug
transport, glomerular filtration and body composition. These processes are subject to …

Transmembrane drug transport in hepatocytes is one of the major determinants of drug
pharmacokinetics. In the present study, ABC transporters (P-gp, MRP1, MRP2, MRP3 …

IL-6 markedly decreases the expression of numerous hepatic transporters. We previously
demonstrated that IL-6-mediated downregulation of transporters occurs through STAT3, with …