Furosemide (FUR) has been used in probe drugs cocktails for in vivo evaluation of the renal
transporters OAT1 and OAT3 activities in studies of drug-drug interactions (generally using …

Emerging information suggests that liver pathological states may affect the expression and
function of membrane transporters in the gastrointestinal tract and the kidney. Altered status …

Introduction Nucleoside analogs are an important class of antiviral agents. Due to the high
hydrophilicity and limited membrane permeability of antiviral nucleoside/nucleotide analogs …

Chimeric mice with humanized livers constitute an attractive emergent experimental model
for investigating human metabolism and disposition of drugs. The present review was …

In recent years, sequence-specific clustered regularly interspaced short palindromic repeats
(CRISPR)-CRISPR-associated (Cas) systems have been widely used in genome editing of …

Abstract Interleukin (IL)-6 decreases hepatic expression of numerous transporters. Although
IL-6 signaling occurs through STAT3, the extent of the involvement of the STAT3 signaling …

Expression and functional changes in the organic anion transporting polypeptide (OATP)–
multidrug resistance–associated protein (MRP) axis of transporters are well reported in …

By controlling the passage of small molecules across lipid bilayers, membrane transporters
influence not only the uptake and efflux of nutrients, but also the metabolic state of the cell …

Epyrifenacil is a novel herbicide that acts as an inhibitor of protoporphyrinogen oxidase
(PPO) and produces hepatotoxicity in rodents by inhibiting PPO. Our previous research …

Drug-metabolizing enzymes and transporters are major determinants of the absorption,
disposition, metabolism, and excretion (ADME) of drugs, and changes in ADME gene …