Transporters govern the access of molecules to cells or their exit from cells, thereby
controlling the overall distribution of drugs to their intracellular site of action. Clinically …

Purpose Considering prior investigations on reductions of renal multidrug resistance-
associated protein (MRP) 2 and 4 transporters in mice with acute lymphoblastic leukemia …

Tripterygium glycosides tablets (TGT) are widely used for treating nephrotic syndrome (NS),
but hepatotoxicity is frequently reported. The presence of underlying disease (s) can alter …

The article discusses model-informed drug development (MIDD) strategies and associated
quantitative approaches have enhanced the design, development, and benefit-risk …

Drug-induced liver injury (DILI) remains a major concern in drug development from a patient
safety perspective because it is the leading cause of acute liver failure. One mechanism of …

Endotoxemia-induced inflammation may impact the activity of hepatocyte transporters, which
control the hepatobiliary elimination of drugs and bile acids. 99mTc-mebrofenin is a non …

Alterations in renal elimination processes of glomerular filtration and active tubular secretion
by renal transporters can result in adverse drug reactions. Nonalcoholic steatohepatitis …

With the rapid progress in pharmaceutical experiments and clinical investigations, extensive
knowledge of drug transporters (DTs) has accumulated, which is valuable data for the …

The multidrug resistance-associated protein 2 (MRP2) mediates the biliary excretion of
drugs and metabolites.[99mTc] mebrofenin may be employed as a probe for hepatic MRP2 …

Transporters regulate trafficking through the biological membrane of living cells and
organelles. Therefore, these proteins play an important role in key cellular processes …