Membrane transporters facilitate the transport of endogenous substances and drugs across
cellular membranes in different tissues and play a pivotal role in organs in which absorption …

Silybum marianum (L.) Gaertn.(Asteraceae), commonly known as milk thistle, is a botanical
natural product used to self‐treat multiple diseases such as Type 2 diabetes mellitus and …

The third trimester of pregnancy is related to physiological changes that can modify the
process of absorption, distribution, metabolism, and excretion and, consequently, the …

IDP-73152, a novel peptide deformylase inhibitor with an antibacterial effect against Gram-
positive bacteria, is in phase I development. The objective of this study was to develop a …

Purpose Drug elimination alteration has been well reported in acute lymphoblastic leukemia
(ALL). Considering that transporters and glomerular filtration influence, to different extents …

Purpose Anti-neutrophilic cytoplasmic antibody (ANCA)–associated vasculitis is a rare
autoimmune disease. Mycophenolic acid (MPA) is widely used for ANCA-associated …

The liver plays a central role in the disposition of endogenous compounds and xenobiotics,
and may act as the primary site of action for certain drugs. Knowledge about hepatic …

Pyrrolizidine alkaloid monocrotaline (MCT) induces sinusoidal obstruction syndrome (SOS)
in rats characterised by a sinusoidal congestive obstruction. Additionally, MCT …

Inflammatory chronic liver diseases (CLD), including nonalcoholic steatohepatitis (NASH),
alcohol-associated liver disease (ALD), hepatitis C virus (HCV), and a combination of ALD …

Cancer is a multifactorial manifestation of diverse complexities linked with its development
and progression. The environment is a source of exposure to multiple carcinogens including …