[HTML][HTML] Spheroids as a type of three-dimensional cell cultures—examples of methods of preparation and the most important application

K Białkowska, P Komorowski, M Bryszewska… - International journal of …, 2020 - mdpi.com
Cell cultures are very important for testing materials and drugs, and in the examination of
cell biology and special cell mechanisms. The most popular models of cell culture are two …

Bridging free radical chemistry with drug discovery: A promising way for finding novel drugs efficiently

ZQ Liu - European Journal of Medicinal Chemistry, 2020 - Elsevier
Many diseases have been regarded to correlate with the in vivo oxidative damages, which
are caused by overproduced free radicals from metabolic process or reactive oxygen …

Fumonisin B1 triggers carcinogenesis via HDAC/PI3K/Akt signalling pathway in human esophageal epithelial cells

S Yu, B Jia, N Liu, D Yu, S Zhang, A Wu - Science of The Total Environment, 2021 - Elsevier
Abstract Fumonisin B1 (FB1) is a contaminant that commonly present in the global
environment, especially in food and feed. Epidemiologic studies have shown that …

[HTML][HTML] Combining preclinical tools and models to unravel tumor complexity: jump into the next dimension

G Miserocchi, M Bocchini, M Cortesi, C Arienti… - Frontiers in …, 2023 - frontiersin.org
Tumors are complex and heterogeneous diseases characterized by an intricate milieu and
dynamically in connection with surrounding and distant tissues. In the last decades, great …

[HTML][HTML] A 3D bioprinted tumor model fabricated with gelatin/sodium alginate/decellularized extracellular matrix bioink

J Xu, S Yang, Y Su, X Hu, Y Xi, YY Cheng… - … journal of bioprinting, 2023 - ncbi.nlm.nih.gov
Abstract 109Tissue-engineered scaffolds are more commonly used to construct three-
dimensional (3D) tumor models for in vitro studies when compared to the conventional two …

[HTML][HTML] Polymeric hydrogels for in vitro 3D ovarian cancer modeling

S Braccini, C Tacchini, F Chiellini, D Puppi - International Journal of …, 2022 - mdpi.com
Ovarian cancer (OC) grows and interacts constantly with a complex microenvironment, in
which immune cells, fibroblasts, blood vessels, signal molecules and the extracellular matrix …

[HTML][HTML] The organoid era permits the development of new applications to study glioblastoma

F Andreatta, G Beccaceci, N Fortuna, M Celotti… - Cancers, 2020 - mdpi.com
Simple Summary Glioblastoma is the most lethal primary adult brain tumor. The great
number of mutations involved and the aggressiveness of glioblastoma render this type of …

[HTML][HTML] Three-dimensional breast cancer model to investigate CCL5/CCR1 expression mediated by direct contact between breast cancer cells and adipose-derived …

M Watzling, L Klaus, T Weidemeier, H Horder, R Ebert… - Cancers, 2023 - mdpi.com
Simple Summary In breast cancer, adipose-derived stromal cells (ASCs) and adipocytes, as
components of the mammary fat pad, come into close contact with tumor cells. To …

[HTML][HTML] Advances in screening hyperthermic nanomedicines in 3D tumor models

JF Soeiro, FL Sousa, MV Monteiro, VM Gaspar… - Nanoscale …, 2024 - pubs.rsc.org
Hyperthermic nanomedicines are particularly relevant for tackling human cancer, providing
a valuable alternative to conventional therapeutics. The early-stage preclinical performance …

3D Co‐culturing of human neuroblastoma and human oligodendrocytes, emulating native tissue using 3D porous biodegradable liquid crystal elastomers

S Ustunel, S Sternbach, ME Prévôt… - Journal of Applied …, 2023 - Wiley Online Library
Biomaterials cover and are an integral part of tissue engineering and regenerative medicine
fields. They are crucial to mimic endogenous tissue responses and help to eliminate high …