Metals to combat antimicrobial resistance

A Frei, AD Verderosa, AG Elliott, J Zuegg… - Nature Reviews …, 2023 - nature.com
Bacteria, similar to most organisms, have a love–hate relationship with metals: a specific
metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions …

Advances in antifungal drug development: an up-to-date mini review

G Bouz, M Doležal - Pharmaceuticals, 2021 - mdpi.com
The utility of clinically available antifungals is limited by their narrow spectrum of activity,
high toxicity, and emerging resistance. Antifungal drug discovery has always been a …

Advanced and biomedical applications of Schiff-base ligands and their metal complexes: A review

A Soroceanu, A Bargan - Crystals, 2022 - mdpi.com
Because of their importance in a variety of interdisciplinary study domains, Schiff-base
ligands have performed a significant role in the evolution of contemporary coordination …

Metal Complexes as Antifungals? From a Crowd-Sourced Compound Library to the First In Vivo Experiments

A Frei, AG Elliott, A Kan, H Dinh, S Bräse, AE Bruce… - JACS au, 2022 - ACS Publications
There are currently fewer than 10 antifungal drugs in clinical development, but new fungal
strains that are resistant to most current antifungals are spreading rapidly across the world …

Visualized Gallium/Lyticase‐Integrated Antifungal Strategy for Fungal Keratitis Treatment

J He, Y Ye, D Zhang, K Yao, M Zhou - Advanced Materials, 2022 - Wiley Online Library
Fungal keratitis has been one of the common corneal infections that causes blindness, but
an effective antifungal strategy remains a challenge. The exopolysaccharides both in the …

A review on the antimicrobial assessment of triazole-azomethine functionalized frameworks incorporating transition metals

W Zafar, M Ashfaq, SH Sumrra - Journal of Molecular Structure, 2023 - Elsevier
Antimicrobial resistance is a growing threat to global public health that calls for innovative
strategies to develop new methods of action against resistance to emerging infectious …

Manganese-based advanced nanoparticles for biomedical applications: future opportunity and challenges

S Haque, S Tripathy, CR Patra - Nanoscale, 2021 - pubs.rsc.org
Nanotechnology is the most promising technology to evolve in the last decade. Recent
research has shown that transition metal nanoparticles especially manganese (Mn)-based …

[HTML][HTML] Repurposing antifungal drugs for cancer therapy

N Weng, Z Zhang, Y Tan, X Zhang, X Wei… - Journal of Advanced …, 2023 - Elsevier
Background Repurposing antifungal drugs in cancer therapy has attracted unprecedented
attention in both preclinical and clinical research due to specific advantages, such as safety …

Beyond silver sulfadiazine: A dive into more than 50 years of research and development on metal complexes of sulfonamides in medicinal inorganic chemistry

JHB Nunes, DH Nakahata, PP Corbi… - Coordination Chemistry …, 2023 - Elsevier
Sulfonamides revolutionized the treatment and management of bacterial infections. Prontosil
was the very first synthetic antibacterial agent ever used in the clinics and its metabolite …

[HTML][HTML] Cytotoxic urea Schiff base complexes for multidrug discovery as anticancer activity and low in vivo oral assessing toxicity

LM Aroua, AN Al-Hakimi, MAM Abdulghani… - Arabian Journal of …, 2022 - Elsevier
Novel mononuclear complexes 2–8 derived from hybrid Urea Schiff base HL were
synthesized using various metal Ni 2+, Fe 3+, Cu 2+, Co 2+, Mn 2+, Zn 2+, and Cr 3+. The …