[HTML][HTML] Pharmacological mechanism of natural drugs and their active ingredients in the treatment of arrhythmia via calcium channel regulation

X Zhang, Y Gao, Y Zhou, Z Liu, R Liu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Arrhythmia is characterized by abnormal heartbeat rhythms and frequencies caused by
heart pacing and conduction dysfunction. Arrhythmia is the leading cause of death in …

[HTML][HTML] Plant-derived natural products targeting ion channels for pain

S Goyal, S Goyal, AE Goins, SRA Alles - Neurobiology of Pain, 2023 - Elsevier
Chronic pain affects approximately one-fifth of people worldwide and reduces quality of life
and in some cases, working ability. Ion channels expressed along nociceptive pathways …

Identification and quantification, metabolism and pharmacokinetics, pharmacological activities, and botanical preparations of protopine: A review

W Huang, L Kong, Y Cao, L Yan - Molecules, 2021 - mdpi.com
Through pharmacological activity research, an increasing number of natural products and
their derivatives are being recognized for their therapeutic value. In recent years, studies …

From Plant to Chemistry: Sources of Active Opioid Antinociceptive Principles for Medicinal Chemistry and Drug Design

R Turnaturi, S Piana, S Spoto, G Costanzo, L Reina… - Molecules, 2023 - mdpi.com
Pain continues to be an enormous global health challenge, with millions of new untreated or
inadequately treated patients reported annually. With respect to current clinical applications …

[HTML][HTML] The composition, pharmacological effects, related mechanisms and drug delivery of alkaloids from Corydalis yanhusuo

J Feng, K Chen, S Shen, Y Luo, X Liu, X Chen… - Biomedicine & …, 2023 - Elsevier
Corydalis yanhusuo WT Wang, also known as yanhusuo, yuanhu, yanhu and xuanhu, is one
of the herb components of many Chinese Traditional Medicine prescriptions such as Jin …

Treatment of gastrointestinal disorders—Plants and potential mechanisms of action of their constituents

S Czigle, S Bittner Fialova, J Tóth, P Mučaji, M Nagy… - Molecules, 2022 - mdpi.com
The worldwide prevalence of gastrointestinal diseases is about 40%, with standard
pharmacotherapy being long-lasting and economically challenging. Of the dozens of …

Natural products as the calcium channel blockers for the treatment of arrhythmia: Advance and prospect

L Xiao, XJ Chen, JK Feng, WN Li, S Yuan, Y Hu - Fitoterapia, 2023 - Elsevier
Arrhythmia is one of the commonly heart diseases with observed abnormal heart-beat
rhythm that caused by the obstacles of cardiac activity and conduction. The arrhythmic …

[HTML][HTML] Exploring the Anti-inflammatory Effects of Protopine Total Alkaloids of Macleaya Cordata (Willd.) R. Br.

Z Dong, Y Wang, Z Tang, C Li, T Jiang… - Frontiers in Veterinary …, 2022 - frontiersin.org
Macleaya cordata (Willd.) R. Br. is a Chinese medicinal plant commonly used externally to
treat inflammatory-related diseases such as arthritis, sores, and carbuncles. This study …

Prediction and verification of potential lead analgesic and antiarrhythmic components in Corydalis yanhusuo WT Wang based on voltage-gated sodium channel …

J Sun, X Liu, S Zhao, S Zhang, L Yang, J Zhang… - International Journal of …, 2022 - Elsevier
Corydalis yanhusuo WT Wang, a traditional Chinese herbal medicine, has been used as an
analgesic for thousands of years and it also promotes blood circulation. In this study, 33 …

Acute, chronic, and genotoxic studies on the protopine total alkaloids of the Macleaya cordata (willd.) R. Br. in rodents

Z Dong, S Tang, X Ma, B Tan, Z Tang, C Li… - Frontiers in …, 2022 - frontiersin.org
The protopine alkaloids are widely distributed within the opium poppy family and have a
wide range of pharmacological effects. MPTA is a product of the protopine total alkaloids …