Molecular genetics of polyamine synthesis in eukaryotic cells

O Heby, L Persson - Trends in biochemical sciences, 1990 - cell.com
Synthetic pathway for the polyamines putrescine, spermidine and spermine in eukaryotic
cells. ODC (1) catalyses the first and usually rate-limiting step in the pathway, the formation …

S-adenosylmenthionine decarboxylase as an enzyme target for therapy

AE Pegg, PP McCann - Pharmacology & therapeutics, 1992 - Elsevier
The polyamine biosynthetic pathway has attracted much interest as a therapeutic target.
Many studies have shown the potential value of inhibitors of the first enzyme in the …

Bioinformatically detectable group of novel regulatory genes and uses thereof

I Bentwich - US Patent 7,250,496, 2007 - Google Patents
The present invention relates to a first group of novel genes, here identified as “genomic
address messenger” or “GAM” genes, and a second group of novel operon-like genes, here …

Cloning and Sequencing of an Intronless Mouse S-Adenosylmethionine Decarboxylase Gene Coding for a Functional Enzyme Strongly Expressed in the Liver (∗)

K Persson, I Holm, O Heby - Journal of Biological Chemistry, 1995 - ASBMB
A genomic clone for a mouse S-adenosylmethionine decarboxylase (AdoMetDC) gene was
isolated from a cosmid library. Surprisingly, the gene proved to be intronless. With the …

[HTML][HTML] Structure and organization of the human S-adenosylmethionine decarboxylase gene.

SC Marić, A Crozat, OA Jänne - Journal of Biological Chemistry, 1992 - Elsevier
Genomic clones for the S-adenosylmethionine (AdoMet) decarboxylase gene were isolated
from a human chromosome 6 DNA library. In addition, polymerase chain reaction and …

Nucleotide sequence of hamster S-adenosylmethionine decarboxylase cDNA

BL Tekwani, BA Stanley, AE Pegg - Biochimica et Biophysica Acta (BBA) …, 1992 - Elsevier
The nucleotide sequence of a cDNA encoding the proenzyme of hamster S-
adenosylmethionine decarboxylase including 169 nucleotides of the 5′ untranslated …

Properties of human and rodent S-adenosylmethionine decarboxylase

AE Pegg, B Stanley, A Pajunen, A Crozat… - Progress in Polyamine …, 1988 - Springer
S-Adenosylmethionine decarboxylase (AdoMetDC) is a key enzyme in the biosynthesis of
the polyamines spermidine and spermine. Its product, decarboxylated S …

CHARACTERIZATION OF TWO PROTEIN-BINDING SITES IN THE SECOND INTRON OF THE MOUSE K-ras GENE

B Chen, Y Wang, M You - Experimental lung research, 2005 - Taylor & Francis
A tandem repeat region in the second intron of the K-ras gene has been reported to be a
possible regulatory site for transcription [You et al. Proc Natl Acad Sci USA. 1992; 89: 5804 …

Ornithine Decarboxylase (ODC) and S-Adenosylmethionine Decarboxylase (AdoMetDC) as Markers in Human Colonic Neoplasia

L Herrera, NJ Petrelli, G Vial - … of the Fourth International Symposium on …, 1990 - Springer
Increased polyamine biosynthetic activity and raised levels of intracellular polyamines are
commonly associated with abnormal and induced proliferative states. Ornithine …

[图书][B] Mechanism of S-adenosylmethionine decarboxylase degradation and changes in substrate S-adenosylmethionine level following inhibition of the 26S …

A Yerlikaya - 2002 - search.proquest.com
S-adenosylmethionine decarboxylase (SAMDC) is a key enzyme in the biosynthesis of
polyamines (putrescine, spermidine and spermine), which are small organic molecules …