Understanding the genetic and molecular drivers of phenotypic heterogeneity across
individuals is central to biology. As new technologies enable fine-grained and spatially …

Importance While air pollutants at historical levels have been associated with cardiovascular
and respiratory diseases, it is not known whether exposure to contemporary air pollutant …

Abstract The World Health Organization estimates that 300 million people have asthma, 210
million people have Chronic Obstructive Pulmonary Disease (COPD), and, according to …

Abstract The Collaborative Cohort of Cohorts for COVID-19 Research (C4R) is a national
prospective study of adults comprising 14 established US prospective cohort studies …

A fully automated, unsupervised lobe segmentation algorithm is presented based on a
probabilistic segmentation of the fissures and the simultaneous construction of a population …

OBJECTIVE. The purpose of this study is to establish whether texture analysis and
densitometry are complementary quantitative measures of chronic obstructive pulmonary …

Background Platelet activation reduces pulmonary microvascular blood flow and contributes
to inflammation; these factors have been implicated in the pathogenesis of COPD and …

Automated tissue classification is an essential step for quantitative analysis and treatment of
emphysema. Although many studies have been conducted in this area, there still remain two …

Lung densitometry is being frequently adopted in CT-based emphysema quantification, yet
known to be affected by the choice of reconstruction kernel. This study presents a two-step …

Unsupervised discovery of pulmonary emphysema subtypes offers the potential for new
definitions of emphysema on lung computed tomography (CT) that go beyond the standard …