The recognition of microbial nucleic acids is a major mechanism by which the immune
system detects pathogens. Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a cytosolic DNA …

Phagocytosis is a fundamental process of cells to capture and ingest foreign particles. Small
unicellular organisms such as free-living amoeba use this process to acquire food. In …

Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease. Tumors are
poorly immunogenic and immunosuppressive, preventing T cell activation in the tumor …

Cells use mitophagy to remove damaged or unwanted mitochondria to maintain
homeostasis. Here we report that the intracellular bacterial pathogen Listeria …

Summary Mitofusin 2 (Mfn2) plays a major role in mitochondrial fusion and in the
maintenance of mitochondria-endoplasmic reticulum contact sites. Given that macrophages …

Parasites and infectious diseases are everywhere and represent some of the most potent
forces shaping the natural world. They affect almost every aspect imaginable in the life of …

Pore-forming toxins (PFTs) are the most common bacterial cytotoxic proteins and are
required for virulence in a large number of important pathogens, including Streptococcus …

Dependable, current, and complete, Robbins and Cotran Pathologic Basis of Disease, 9th
Edition is the perennially best-selling text that you'll use long after your medical student days …

Summary A naive CD4+ T cell population specific for a microbial peptide: major
histocompatibility complex II ligand (p: MHCII) typically consists of about 100 cells, each with …

Professional phagocytes have a vast and sophisticated arsenal of microbicidal features.
They are capable of ingesting and destroying invading organisms, and can present …