Background: The adherens protein VE-cadherin (vascular endothelial cadherin) has diverse
roles in organ-specific lymphatic vessels. However, its physiological role in cardiac …

The mammalian vascular system consists of two networks: the blood vascular system and
the lymphatic vascular system. Throughout the body, the lymphatic system contributes to …

Background Promoting cardiac lymphangiogenesis exerts beneficial effects for the heart.
Exercise can induce physiological cardiac growth with cardiomyocyte hypertrophy and …

Impairment of cardiac lymphatic vessels leads to cardiac lymphedema. Recent studies have
suggested that stimulation of lymphangiogenesis may reduce cardiac lymphedema …

We have shown that systemic and cardiac sympathetic activation is present in heart failure
with preserved ejection fraction (HFpEF) patients. Conversely, whereas systemic …

Cardiovascular disease is the leading cause of death around the world, in which myocardial
infarction (MI) is a precipitating event. However, current therapies do not adequately address …

Human lung mast cells (HLMCs) express the high-affinity receptor FcεRI for IgE and are
strategically located in different compartments of human lung, where they play a role in …

The heart is imbued with a vast lymphatic network that is responsible for fluid homeostasis
and immune cell trafficking. Disturbances in the forces that regulate microvascular fluid …

Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation,
predominantly affecting the lung parenchyma and peripheral airways, that results in …

The lymphatic vasculature is involved in the pathogenesis of acute cardiac injuries, but little
is known about its role in chronic cardiac dysfunction. Here, we demonstrate that …