Drugs are commonly administered via the intraperitoneal (IP) route to treat localized
infections and cancers in patients and to test drug efficacy and toxicity in preclinical studies …

Cardiac lymphangiogenesis plays an important physiological role in the regulation of
interstitial fluid homeostasis, inflammatory, and immune responses. Impaired or excessive …

Acute myocardial infarction (MI) is a prevalent and highly fatal global disease. Despite
significant reduction in mortality rates with standard treatment regimens, the risk of heart …

The tumor microenvironment (TME) is an intricate complex and dynamic structure composed
of various cell types, including tumor, stromal and immune cells. Within this complex …

Cardioprotective medication is the common treatment to relieve myocardial
ischemia/reperfusion (I/R) injury. However, limited by the low bioavailability of therapeutic …

As an integral part of the vascular system, the lymphatic vasculature is essential for tissue
fluid homeostasis, nutritional lipid assimilation and immune regulation. The composition of …

In recent years, the lymphatic system has received increasing attention due to the fast-
growing number of findings about its diverse novel functional roles in health and disease. It …

Abstract Purpose of Review Kidney disease is a strong modulator of the composition and
metabolism of the intestinal microbiome that produces toxins and inflammatory factors. The …

Background The lymphatic contribution to the circulation is of paramount importance in
regulating fluid homeostasis, immune cell trafficking/activation and lipid metabolism. In …

Recent advances in RNA sequencing technologies helped uncover what was once
uncharted territory in the human genome—the complex and versatile world of long …