Human cardiac fibroblasts expressing VCAM1 improve heart function in postinfarct heart failure rat models by stimulating lymphangiogenesis

T Iwamiya, BD Segard, Y Matsuoka, T Imamura - PLoS One, 2020 - journals.plos.org
Cardiovascular diseases are a leading cause of death worldwide. After an ischemic injury,
the myocardium undergoes severe necrosis and apoptosis, leading to a dramatic …

Lymphatic endothelial sphingosine 1-phosphate receptor 1 enhances macrophage clearance via lymphatic system following myocardial infarction

Q Li, C Zhou, K Zhao, Y Duan, J Yue, X Liu… - Frontiers in …, 2022 - frontiersin.org
Lymphatic endothelial cell homeostasis plays important roles in normal physiological
cardiac functions, and its dysfunction significantly influences pathological cardiac …

Homeostatic maintenance of the lymphatic vasculature

S Stritt, K Koltowska, T Mäkinen - Trends in Molecular Medicine, 2021 - cell.com
The lymphatic vasculature is emerging as a multifaceted regulator of tissue homeostasis and
regeneration. Lymphatic vessels drain fluid, macromolecules, and immune cells from …

15-Lipoxygenase promotes resolution of inflammation in lymphedema by controlling Treg cell function through IFN-β

A Zamora, M Nougué, L Verdu, E Balzan… - Nature …, 2024 - nature.com
Lymphedema (LD) is characterized by the accumulation of interstitial fluid, lipids and
inflammatory cell infiltrate in the limb. Here, we find that LD tissues from women who …

Differential regulation of lymphatic junctional morphology and the potential effects on cardiovascular diseases

AM Peluzzo, M Bkhache, LNH Do, MV Autieri… - Frontiers in …, 2023 - frontiersin.org
The lymphatic vasculature provides an essential route to drain fluid, macromolecules, and
immune cells from the interstitium as lymph, returning it to the bloodstream where the …

Tenascin-C in tissue repair after myocardial infarction in humans

K Matsui, S Torii, S Hara, K Maruyama, T Arai… - International Journal of …, 2023 - mdpi.com
Adverse ventricular remodeling after myocardial infarction (MI) is progressive ventricular
dilatation associated with heart failure for weeks or months and is currently regarded as the …

HIV gp120 induces the release of proinflammatory, angiogenic, and lymphangiogenic factors from human lung mast cells

G Marone, FW Rossi, A Pecoraro, V Pucino… - Vaccines, 2020 - mdpi.com
Human lung mast cells (HLMCs) express the high-affinity receptor FcεRI for IgE and are
involved in chronic pulmonary diseases occurring at high frequency among HIV-infected …

Intrinsic and extrinsic contributors to the cardiac benefits of exercise

MH Hastings, C Castro, R Freeman… - Basic to Translational …, 2024 - jacc.org
Among its many cardiovascular benefits, exercise training improves heart function and
protects the heart against age-related decline, pathological stress, and injury. Here, we …

MiR-153 regulates cardiomyocyte apoptosis by targeting Nrf2/HO-1 signaling

X Zhu, Y Zhao, W Hou, L Guo - Chromosome Research, 2019 - Springer
MicroRNAs (miRNAs) play various roles in the regulation of human disease, including
cardiovascular diseases. MiR-153 has been previously shown to be involved in regulating …

Cardiac and intestinal tissue conduct developmental and reparative processes in response to lymphangiocrine signaling

S Kurup, C Tan, T Kume - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
Lymphatic vessels conduct a diverse range of activities to sustain the integrity of surrounding
tissue. Besides facilitating the movement of lymph and its associated factors, lymphatic …