The Nrf2 transcription factor governs the expression of hundreds genes involved in cell
defense against oxidative stress, the hallmark of numerous diseases such as …

Exposure to antioxidants and xenobiotics triggers the expression of a myriad of genes
encoding antioxidant proteins, detoxifying enzymes, and xenobiotic transporters to offer …

Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety
of age-related pathologies. In aging, oxidant production from several sources is increased …

The nuclear factor erythroid 2 related factor 2 (NRF2) is a key regulator of endogenous
inducible defense systems in the body. Under physiological conditions NRF2 is mainly …

The transcription factor BTB and CNC homology 1 (Bach1) is widely expressed in most
mammalian tissues and functions primarily as a transcriptional suppressor by …

Increase in life-span is commonly related with age-related diseases and with gradual loss of
genomic, proteomic and metabolic integrity. Nrf2 (Nuclear factor-erythroid 2-p45 derived …

Hyperglycemia/oxidative stress has been implicated in the initiation and progression of
diabetic complications while the components of Keap1/Nrf2/ARE signaling are being …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is an essential component of cellular
defense against a vast variety of endogenous and exogenous insults, including oxidative …

Background Oxidative stress is one of the important factors involved in the pathogenesis of
idiopathic pulmonary fibrosis (IPF). The equilibrium of Nuclear factor-erythroid-related factor …

The Nrf2–Keap1 system plays a major role in cellular defense against oxidative stress. Upon
exposure to electrophiles, the cysteine-rich protein Keap1 is covalently modified, and it is …