An introduction to epitope prediction methods and software

X Yang, X Yu - Reviews in medical virology, 2009 - Wiley Online Library
In this paper, current prediction methods and algorithms for both T‐and B cell epitopes are
reviewed, and a comprehensive summary of epitope prediction software and databases …

An overview of in silico vaccine design against different pathogens and cancer

K Kardani, A Bolhassani, A Namvar - Expert Review of Vaccines, 2020 - Taylor & Francis
Introduction Due to overcome the hardness of the vaccine design, computational
vaccinology is emerging widely. Prediction of T cell and B cell epitopes, antigen processing …

Reliable prediction of T‐cell epitopes using neural networks with novel sequence representations

M Nielsen, C Lundegaard, P Worning… - Protein …, 2003 - Wiley Online Library
In this paper we describe an improved neural network method to predict T‐cell class I
epitopes. A novel input representation has been developed consisting of a combination of …

Distance‐scaled, finite ideal‐gas reference state improves structure‐derived potentials of mean force for structure selection and stability prediction

H Zhou, Y Zhou - Protein science, 2002 - Wiley Online Library
The distance‐dependent structure‐derived potentials developed so far all employed a
reference state that can be characterized as a residue (atom)‐averaged state. Here, we …

Benchmarking predictions of MHC class I restricted T cell epitopes in a comprehensively studied model system

S Paul, NP Croft, AW Purcell, DC Tscharke… - PLoS computational …, 2020 - journals.plos.org
T cell epitope candidates are commonly identified using computational prediction tools in
order to enable applications such as vaccine design, cancer neoantigen identification …

Immuno‐informatics: Mining genomes for vaccine components

AS De Groot, H Sbai, CS Aubin… - Immunology and cell …, 2002 - Wiley Online Library
The complete genome sequences of more than 60 microbes have been completed in the
past decade. Concurrently, a series of new informatic stools, designed to harness this new …

Structure-derived potentials and protein simulations

RL Jernigan, I Bahar - Current opinion in structural biology, 1996 - Elsevier
There has recently been an explosion in the number of structure-derived potential functions
that are based on the increasing number of high-resolution protein crystal structures. These …

From genome to vaccine: in silico predictions, ex vivo verification

AS De Groot, A Bosma, N Chinai, J Frost, BM Jesdale… - Vaccine, 2001 - Elsevier
Bioinformatics tools enable researchers to move rapidly from genome sequence to vaccine
design. EpiMer and EpiMatrix are computer-driven pattern-matching algorithms that identify …

Self‐consistent estimation of inter‐residue protein contact energies based on an equilibrium mixture approximation of residues

S Miyazawa, RL Jernigan - Proteins: Structure, Function, and …, 1999 - Wiley Online Library
Pairwise contact energies for 20 types of residues are estimated self‐consistently from the
actual observed frequencies of contacts with regression coefficients that are obtained by …

EpiJen: a server for multistep T cell epitope prediction

IA Doytchinova, P Guan, DR Flower - BMC bioinformatics, 2006 - Springer
Background The main processing pathway for MHC class I ligands involves degradation of
proteins by the proteasome, followed by transport of products by the transporter associated …