Spinal cord injury (SCI) results in devastating neurological and pathological consequences,
causing major dysfunction to the motor, sensory, and autonomic systems. The primary …

Chondroitin sulphate proteoglycans (CSPGs) are potent inhibitors of growth in the adult
CNS. Use of the enzyme chondroitinase ABC (ChABC) as a strategy to reduce CSPG …

Contusive spinal cord injury leads to a variety of disabilities owing to limited neuronal
regeneration and functional plasticity. It is well established that an upregulation of glial …

Strategies for spinal cord injury repair are limited, in part, by poor drug delivery techniques.
A novel drug delivery system (DDS) is being developed in our laboratory that can provide …

Traumatic injury to the spinal cord causes cell death, demyelination, axonal degeneration,
and cavitation resulting in functional motor and sensory loss. Stem cell therapy is a …

Stroke is the leading cause of adult disability. Systemic delivery of candidate neural repair
therapies is limited by the blood–brain barrier and off-target effects. We tested a …

Cellular transplantation strategies for repairing the injured spinal cord have shown
consistent benefit in preclinical models, and human clinical trials have begun. Interactions …

Brain and spinal cord injury can result in permanent cognitive, motor, sensory and
autonomic deficits. The central nervous system (CNS) has a poor intrinsic capacity for …

Despite enormous advances made in the development of external effector prosthetics over
the last quarter century, significant questions remain, especially those concerning signal …

We report the development of a series of physical hydrogel blends composed of hyaluronan
(HA) and methyl cellulose (MC) designed for independent delivery of one or more drugs …