Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …

As resident macrophages of the CNS, microglia are critical immune effectors of inflammatory
lesions and associated neural dysfunctions. In multiple sclerosis (MS) and its animal …

To dissect therapeutic mechanisms of transplanted stem cells and develop exosome-based
nanotherapeutics in treating autoimmune and neurodegenerative diseases, we assessed …

While many drugs are effective at reducing the relapse frequency of multiple sclerosis (MS),
there is an unmet need for treatments that slow neurodegeneration resulting from secondary …

Glial cells and central nervous system (CNS)-infiltrating leukocytes contribute to multiple
sclerosis (MS). However, the networks that govern crosstalk among these ontologically …

In diseases such as multiple sclerosis (MS), inflammation can injure the myelin sheath that
surrounds axons, a process known as demyelination. The spontaneous regeneration of …

Pathologic roles of innate immunity in neurologic disorders are well described, but their
beneficial aspects are less understood. Dectin-1, a C-type lectin receptor (CLR), is largely …

Multiple sclerosis (MS) treatment has received much attention, yet there is still no certain
cure. We herein investigate the therapeutic effect of olean-12-en-28-ol, 3β-pentacosanoate …

Objective Accumulating evidence suggests that dysfunctional adipose tissue (AT) plays a
major role in the risk of developing multiple sclerosis (MS), the most common immune …

The central nervous system (CNS) parenchyma is enclosed and protected by a multilayered
system of cellular and acellular barriers, functionally separating glia and neurons from …