A potential therapeutic approach for ulcerative colitis: targeted regulation of macrophage polarization through phytochemicals

K Wang, T Mao, X Lu, M Wang, Y Yun, Z Jia… - Frontiers in …, 2023 - frontiersin.org
Ulcerative colitis (UC), a type of inflammatory bowel disease characterized by recurring and
incurable symptoms, causes immense suffering and economic burden for patients due to the …

Berberine a traditional Chinese drug repurposing: Its actions in inflammation-associated ulcerative colitis and cancer therapy

C Zhu, K Li, XX Peng, TJ Yao, ZY Wang, P Hu… - Frontiers in …, 2022 - frontiersin.org
Berberine (BBR), an isoquinoline alkaloid extracted from Coptidis Rhizoma, has a long
history of treating dysentery in the clinic. Over the past two decades, the polytrophic …

The role of AMPK in macrophage metabolism, function and polarisation

Y Cui, J Chen, Z Zhang, H Shi, W Sun, Q Yi - Journal of Translational …, 2023 - Springer
AMP-activated protein kinase (AMPK) is a ubiquitous sensor of energy and nutritional status
in eukaryotic cells. It plays a key role in regulating cellular energy homeostasis and multiple …

Sea cucumber peptides ameliorate DSS-induced ulcerative colitis: the role of the gut microbiota, the intestinal barrier, and macrophage polarization

S Yu, H Guo, Z Ji, Y Zheng, B Wang, Q Chen, H Tang… - Nutrients, 2023 - mdpi.com
The incidence of ulcerative colitis (UC) is increasing annually. There are few treatments for
UC patients, and some drugs have serious side effects. Sea cucumber peptide (SCP) has …

Luteolin ameliorates DSS-induced colitis in mice via suppressing macrophage activation and chemotaxis

L Xue, X Jin, T Ji, R Li, X Zhuge, F Xu, Z Quan… - International …, 2023 - Elsevier
Objectives Luteolin, known for its multifaceted therapeutic properties against inflammatory
diseases, holds potential for addressing the unmet need for effective treatments in ulcerative …

Macrophage polarization: an important role in inflammatory diseases

M Luo, F Zhao, H Cheng, M Su, Y Wang - Frontiers in Immunology, 2024 - frontiersin.org
Macrophages are crucial cells in the human body's innate immunity and are engaged in a
variety of non-inflammatory reactions. Macrophages can develop into two kinds when …

Dexamethasone-Loaded Lipid Calcium Phosphate Nanoparticles Treat Experimental Colitis by Regulating Macrophage Polarization in Inflammatory Sites

K Dong, Y Zhang, HR Ji, ZL Guan… - International journal …, 2024 - Taylor & Francis
Background The M1/M2 polarization of intestinal macrophages exerts an essential function
in the pathogenesis of ulcerative colitis (UC), which can be adjusted to alleviate the UC …

Ethyl acetate extract of Terminalia chebula alleviates DSS-induced ulcerative colitis in C57BL/6 mice

WR Dong, YY Li, TT Liu, G Zhou… - Frontiers in Pharmacology, 2023 - frontiersin.org
Background: The Chinese pharmacopeia records Terminalia chebula as effective in treating
prolonged diarrhea and dysentery, blood in the stool, and prolapse. Modern …

[HTML][HTML] Unraveling the mechanism of ethyl acetate extract from Prismatomeris connata YZ Ruan root in treating pulmonary fibrosis: insights from bioinformatics …

S Li, G Hu, L Kuang, T Zhou, H Jiang, F Pang… - Frontiers in …, 2024 - frontiersin.org
Introduction Pulmonary fibrosis is a terminal lung disease characterized by fibroblast
proliferation, extracellular matrix accumulation, inflammatory damage, and tissue structure …

[HTML][HTML] Protective effects of Amauroderma rugosum on dextran sulfate sodium-induced ulcerative colitis through the regulation of macrophage polarization and …

J Li, X Luo, PHT Shiu, Y Cheng, X Nie… - Biomedicine & …, 2024 - Elsevier
Background Amauroderma rugosum (AR) is a medicinal mushroom commonly used to treat
inflammation, gastric disorders, epilepsy, and cancers due to its remarkable anti …