Altered functional connectivity of the basal nucleus of Meynert in subjective cognitive impairment, early mild cognitive impairment, and late mild cognitive impairment

W Xu, J Rao, Y Song, S Chen, C Xue, G Hu… - Frontiers in Aging …, 2021 - frontiersin.org
Background: The spectrum of early Alzheimer's disease (AD) is thought to include subjective
cognitive impairment, early mild cognitive impairment (eMCI), and late mild cognitive …

current quest in natural bioactive compounds for Alzheimer's disease: Multi-targeted-designed-ligand based approach with preclinical and clinical based evidence

A Iqubal, SO Rahman, M Ahmed, P Bansal… - Current Drug …, 2021 - ingentaconnect.com
Alzheimer's disease is a common and most chronic neurological disorder (NDs) associated
with cognitive dysfunction. Pathologically, Alzheimer's disease (AD) is characterized by the …

Early loss of locus coeruleus innervation promotes cognitive and neuropathological changes before amyloid plaque deposition in a transgenic rat model of …

L Flores‐Aguilar, H Hall, C Orciani… - Neuropathology and …, 2022 - Wiley Online Library
Aims The locus coeruleus (LC) is the main source of noradrenaline (NA) in the mammalian
brain and has been found to degenerate during the initial stages of Alzheimer's disease …

Characterization of Human Genes Modulated by Porphyromonas gingivalis Highlights the Ribosome, Hypothalamus, and Cholinergic Neurons

S Patel, D Howard, N Chowdhury, C Derieux… - Frontiers in …, 2021 - frontiersin.org
Porphyromonas gingivalis, a bacterium associated with periodontal disease, is a suspected
cause of Alzheimer's disease. This bacterium is reliant on gingipain proteases, which cleave …

Recent Advancements in the Treatment of Alzheimer's Disease: A Multitarget-directed Ligand Approach

S Kumar, A Mahajan, R Ambatwar… - Current Medicinal …, 2024 - ingentaconnect.com
Alzheimer's disease (AD) is a neurodegenerative disease and one of the leading causes of
progressive dementia, affecting 50 million people worldwide. Many pathogenic processes …

[PDF][PDF] Anti-amnesic and anti-cholinesterase activities of α-asarone against scopolamine-induced memory impairments in rats.

K Venkatesan - European Review for Medical & …, 2022 - europeanreview.org
OBJECTIVE: Alzheimer's disease (AD) is a neurological ailment that causes memory loss
and impairments and is linked to a drop-in acetylcholine level. Acetylcholinesterase (AChE) …

Animal and cellular models of Alzheimer's disease: Progress, promise, and future approaches

L Trujillo-Estrada, E Sanchez-Mejias… - The …, 2022 - journals.sagepub.com
Alzheimer's disease (AD) is an incurable neurodegenerative disease affecting over 45
million people worldwide. Transgenic mouse models have made remarkable contributions …

Peripheral pathways to neurovascular unit dysfunction, cognitive impairment, and Alzheimer's Disease

AR Nelson - Frontiers in aging neuroscience, 2022 - frontiersin.org
Alzheimer's disease (AD) is the most common form of dementia. It was first described more
than a century ago, and scientists are acquiring new data and learning novel information …

[HTML][HTML] Ethanol extract of Evodia lepta Merr. ameliorates cognitive impairment through inhibiting NLRP3 inflammasome in scopolamine-treated mice

RD Hu, WL Zhu, WY Lin, YH Qiu, GL Wu… - Aging (Albany …, 2024 - ncbi.nlm.nih.gov
Abstract Evodia lepta Merr.(Evodia lepta) is a well-known traditional Chinese medicine,
which has been widely used in herbal tea. We previously reported that the coumarin …

Rapid screening for acetylcholinesterase inhibitors in Selaginella doederleinii Hieron by using functionalized magnetic Fe3O4 nanoparticles

F Zhang, S Li, C Liu, K Fang, Y Jiang, J Zhang, J Lan… - Talanta, 2022 - Elsevier
Insufficient acetylcholine (ACh) can cause cognitive and memory dysfunction, clinically
known as, Alzheimer's disease (AD). Acetylcholinesterase (AChE) can hydrolyze ACh into …