Metformin increases exosome biogenesis and secretion in U87 MG human glioblastoma cells: a possible mechanism of therapeutic resistance
Background Glioblastoma multiforme (GBM) is the most common and aggressive brain
tumor. Metformin, an anti-diabetic drug, can suppress tumor cells. Exosomes from GBM cells …
tumor. Metformin, an anti-diabetic drug, can suppress tumor cells. Exosomes from GBM cells …
[HTML][HTML] Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition
MK Crist, B Yaniv, S Palackdharry… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Original research: Metformin increases natural killer cell functions in head and neck squamous
cell carcinoma through CXCL1 inhibition - PMC Back to Top Skip to main content NIH NLM …
cell carcinoma through CXCL1 inhibition - PMC Back to Top Skip to main content NIH NLM …
The anticancer potential of metformin on prostate cancer
S Zaidi, J Gandhi, G Joshi, NL Smith… - Prostate cancer and …, 2019 - nature.com
Abstract Background Prostate cancer (PCa) is characterized as the most frequent type of
cancer in males. Recent research has suggested patients who have diabetes mellitus taking …
cancer in males. Recent research has suggested patients who have diabetes mellitus taking …
Lessons learned from two decades of anticancer drugs
Tremendous efforts have been made to elucidate the basis of cancer biology with the aim of
promoting anticancer drug development. Especially over the past 20 years, anticancer drug …
promoting anticancer drug development. Especially over the past 20 years, anticancer drug …
Mechanisms of cancer cell killing by metformin: a review on different cell death pathways
X Wu, WW Xu, X Huan, G Wu, G Li, YH Zhou… - Molecular and cellular …, 2023 - Springer
Cancer resistance to anti-tumour agents has been one of the serious challenges in different
types of cancer treatment. Usually, an increase in the cell death markers can predict a higher …
types of cancer treatment. Usually, an increase in the cell death markers can predict a higher …
[HTML][HTML] Metformin suppresses hypoxia-induced stabilization of HIF-1α through reprogramming of oxygen metabolism in hepatocellular carcinoma
X Zhou, J Chen, G Yi, M Deng, H Liu, M Liang… - …, 2015 - pmc.ncbi.nlm.nih.gov
Overexpression of hypoxia-induced factor 1α (HIF-1α) has been shown to be involved in the
development and progression of hepatocellular carcinoma (HCC). HIF-1α should therefore …
development and progression of hepatocellular carcinoma (HCC). HIF-1α should therefore …
Tumor mechanics and metabolic dysfunction
JC Tung, JM Barnes, SR Desai, C Sistrunk… - Free Radical Biology …, 2015 - Elsevier
Desmosplasia is a characteristic of most solid tumors and leads to fibrosis through abnormal
extracellular matrix (ECM) deposition, remodeling, and posttranslational modifications. The …
extracellular matrix (ECM) deposition, remodeling, and posttranslational modifications. The …
Metformin and breast cancer: molecular targets
J Faria, G Negalha, A Azevedo, F Martel - Journal of mammary gland …, 2019 - Springer
Metformin has been the first-line drug for the treatment of type II diabetes mellitus for
decades, being presently the most widely prescribed antihyperglycemic drug. Retrospective …
decades, being presently the most widely prescribed antihyperglycemic drug. Retrospective …
Artemisinin and its derivatives as a repurposing anticancer agent: what else do we need to do?
Z Li, Q Li, J Wu, M Wang, J Yu - Molecules, 2016 - mdpi.com
Preclinical investigation and clinical experience have provided evidence on the potential
anticancer effect of artemisinin and its derivatives (ARTs) in the recent two decades. The …
anticancer effect of artemisinin and its derivatives (ARTs) in the recent two decades. The …
Effect of metformin monotherapy on serum lipid profile in statin-naïve individuals with newly diagnosed type 2 diabetes mellitus: a cohort study
SH Lin, PC Cheng, S Te Tu, SR Hsu, YC Cheng… - PeerJ, 2018 - peerj.com
Background Cardiovascular disease is a major cause of mortality and morbidity in people
with type 2 diabetes mellitus (T2DM). Studies have consistently identified dyslipidemia as an …
with type 2 diabetes mellitus (T2DM). Studies have consistently identified dyslipidemia as an …