Metformin increases exosome biogenesis and secretion in U87 MG human glioblastoma cells: a possible mechanism of therapeutic resistance

H Soraya, NA Sani, N Jabbari, J Rezaie - Archives of Medical Research, 2021 - Elsevier
Background Glioblastoma multiforme (GBM) is the most common and aggressive brain
tumor. Metformin, an anti-diabetic drug, can suppress tumor cells. Exosomes from GBM cells …

[HTML][HTML] Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition

MK Crist, B Yaniv, S Palackdharry… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Original research: Metformin increases natural killer cell functions in head and neck squamous
cell carcinoma through CXCL1 inhibition - PMC Back to Top Skip to main content NIH NLM …

The anticancer potential of metformin on prostate cancer

S Zaidi, J Gandhi, G Joshi, NL Smith… - Prostate cancer and …, 2019 - nature.com
Abstract Background Prostate cancer (PCa) is characterized as the most frequent type of
cancer in males. Recent research has suggested patients who have diabetes mellitus taking …

Lessons learned from two decades of anticancer drugs

Z Liu, B Delavan, R Roberts, W Tong - Trends in pharmacological sciences, 2017 - cell.com
Tremendous efforts have been made to elucidate the basis of cancer biology with the aim of
promoting anticancer drug development. Especially over the past 20 years, anticancer drug …

Mechanisms of cancer cell killing by metformin: a review on different cell death pathways

X Wu, WW Xu, X Huan, G Wu, G Li, YH Zhou… - Molecular and cellular …, 2023 - Springer
Cancer resistance to anti-tumour agents has been one of the serious challenges in different
types of cancer treatment. Usually, an increase in the cell death markers can predict a higher …

[HTML][HTML] Metformin suppresses hypoxia-induced stabilization of HIF-1α through reprogramming of oxygen metabolism in hepatocellular carcinoma

X Zhou, J Chen, G Yi, M Deng, H Liu, M Liang… - …, 2015 - pmc.ncbi.nlm.nih.gov
Overexpression of hypoxia-induced factor 1α (HIF-1α) has been shown to be involved in the
development and progression of hepatocellular carcinoma (HCC). HIF-1α should therefore …

Tumor mechanics and metabolic dysfunction

JC Tung, JM Barnes, SR Desai, C Sistrunk… - Free Radical Biology …, 2015 - Elsevier
Desmosplasia is a characteristic of most solid tumors and leads to fibrosis through abnormal
extracellular matrix (ECM) deposition, remodeling, and posttranslational modifications. The …

Metformin and breast cancer: molecular targets

J Faria, G Negalha, A Azevedo, F Martel - Journal of mammary gland …, 2019 - Springer
Metformin has been the first-line drug for the treatment of type II diabetes mellitus for
decades, being presently the most widely prescribed antihyperglycemic drug. Retrospective …

Artemisinin and its derivatives as a repurposing anticancer agent: what else do we need to do?

Z Li, Q Li, J Wu, M Wang, J Yu - Molecules, 2016 - mdpi.com
Preclinical investigation and clinical experience have provided evidence on the potential
anticancer effect of artemisinin and its derivatives (ARTs) in the recent two decades. The …

Effect of metformin monotherapy on serum lipid profile in statin-naïve individuals with newly diagnosed type 2 diabetes mellitus: a cohort study

SH Lin, PC Cheng, S Te Tu, SR Hsu, YC Cheng… - PeerJ, 2018 - peerj.com
Background Cardiovascular disease is a major cause of mortality and morbidity in people
with type 2 diabetes mellitus (T2DM). Studies have consistently identified dyslipidemia as an …