Metformin use and the risk of total knee replacement among diabetic patients: a propensity-score-matched retrospective cohort study
Metformin has been shown to modulate meta-inflammation, an important pathogenesis in
knee osteoarthritis (OA). The study aimed to test the association between regular metformin …
knee osteoarthritis (OA). The study aimed to test the association between regular metformin …
[HTML][HTML] Decavanadate salts of cytosine and metformin: a combined experimental-theoretical study of potential metallodrugs against diabetes and cancer
E Sánchez-Lara, S Treviño, BL Sánchez-Gaytán… - Frontiers in …, 2018 - frontiersin.org
Cytosine, a DNA and RNA building-block, and Metformin, the most widely prescribed drug
for the treatment of Type 2 Diabetes mellitus were made to react separately with ammonium …
for the treatment of Type 2 Diabetes mellitus were made to react separately with ammonium …
[HTML][HTML] miR-708-5p: a microRNA with emerging roles in cancer
NJ Monteleone, CS Lutz - Oncotarget, 2017 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression
post-transcriptionally. They are crucial for normal development and maintaining …
post-transcriptionally. They are crucial for normal development and maintaining …
Network based approach to identify interactions between Type 2 diabetes and cancer comorbidities
High blood sugar and insulin insensitivity causes the lifelong chronic metabolic disease
called Type 2 diabetes (T2D) which has a higher chance of developing different …
called Type 2 diabetes (T2D) which has a higher chance of developing different …
[HTML][HTML] Tumor metabolism regulating chemosensitivity in ovarian cancer
Elevated metabolism is a key hallmark of multiple cancers, serving to fulfill high anabolic
demands. Ovarian cancer (OVCA) is the fifth leading cause of cancer deaths in women with …
demands. Ovarian cancer (OVCA) is the fifth leading cause of cancer deaths in women with …
Methylglyoxal-mediated stress correlates with high metabolic activity and promotes tumor growth in colorectal cancer
B Chiavarina, MJ Nokin, J Bellier, F Durieux… - International journal of …, 2017 - mdpi.com
Cancer cells generally rely on aerobic glycolysis as a major source of energy. Methylglyoxal
(MG), a dicarbonyl compound that is produced as a side product during glycolysis, is highly …
(MG), a dicarbonyl compound that is produced as a side product during glycolysis, is highly …
[HTML][HTML] Metformin for cancer and aging prevention: is it a time to make the long story short?
VN Anisimov - Oncotarget, 2015 - ncbi.nlm.nih.gov
During the last decade, the burst of interest is observed to antidiabetic biguanide metformin
as candidate drug for cancer chemoprevention. The analysis of the available data have …
as candidate drug for cancer chemoprevention. The analysis of the available data have …
Targeting cancer stem‐like cells in glioblastoma and colorectal cancer through metabolic pathways
UD Kahlert, SM Mooney, M Natsumeda… - … Journal of Cancer, 2017 - Wiley Online Library
Cancer stem‐like cells (CSCs) are thought to be the main cause of tumor occurrence,
progression and therapeutic resistance. Strong research efforts in the last decade have led …
progression and therapeutic resistance. Strong research efforts in the last decade have led …
Biguanides drugs: past success stories and promising future for drug discovery
O Grytsai, I Myrgorodska, S Rocchi, C Ronco… - European Journal of …, 2021 - Elsevier
Biguanides have attracted much attention a century ago and showed resurgent interest in
recent years after a long period of dormancy. They constitute an important class of …
recent years after a long period of dormancy. They constitute an important class of …
Combining naringenin and metformin with doxorubicin enhances anticancer activity against triple-negative breast cancer in vitro and in vivo
B Pateliya, V Burade, S Goswami - European journal of pharmacology, 2021 - Elsevier
Triple-negative breast cancer (TNBC) grows fast and represents poor prognosis and
management. This work is aimed to determine the effect of concomitant use of naringenin …
management. This work is aimed to determine the effect of concomitant use of naringenin …