Metformin use and the risk of total knee replacement among diabetic patients: a propensity-score-matched retrospective cohort study

FTT Lai, BHK Yip, DJ Hunter, DP Rabago, CD Mallen… - Scientific reports, 2022 - nature.com
Metformin has been shown to modulate meta-inflammation, an important pathogenesis in
knee osteoarthritis (OA). The study aimed to test the association between regular metformin …

[HTML][HTML] Decavanadate salts of cytosine and metformin: a combined experimental-theoretical study of potential metallodrugs against diabetes and cancer

E Sánchez-Lara, S Treviño, BL Sánchez-Gaytán… - Frontiers in …, 2018 - frontiersin.org
Cytosine, a DNA and RNA building-block, and Metformin, the most widely prescribed drug
for the treatment of Type 2 Diabetes mellitus were made to react separately with ammonium …

[HTML][HTML] miR-708-5p: a microRNA with emerging roles in cancer

NJ Monteleone, CS Lutz - Oncotarget, 2017 - ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are small non-coding RNAs that negatively regulate gene expression
post-transcriptionally. They are crucial for normal development and maintaining …

Network based approach to identify interactions between Type 2 diabetes and cancer comorbidities

SI Nayan, MH Rahman, MM Hasan, SMRH Raj… - Life Sciences, 2023 - Elsevier
High blood sugar and insulin insensitivity causes the lifelong chronic metabolic disease
called Type 2 diabetes (T2D) which has a higher chance of developing different …

[HTML][HTML] Tumor metabolism regulating chemosensitivity in ovarian cancer

CY Han, DA Patten, RB Richardson, ME Harper… - Genes & …, 2018 - ncbi.nlm.nih.gov
Elevated metabolism is a key hallmark of multiple cancers, serving to fulfill high anabolic
demands. Ovarian cancer (OVCA) is the fifth leading cause of cancer deaths in women with …

Methylglyoxal-mediated stress correlates with high metabolic activity and promotes tumor growth in colorectal cancer

B Chiavarina, MJ Nokin, J Bellier, F Durieux… - International journal of …, 2017 - mdpi.com
Cancer cells generally rely on aerobic glycolysis as a major source of energy. Methylglyoxal
(MG), a dicarbonyl compound that is produced as a side product during glycolysis, is highly …

[HTML][HTML] Metformin for cancer and aging prevention: is it a time to make the long story short?

VN Anisimov - Oncotarget, 2015 - ncbi.nlm.nih.gov
During the last decade, the burst of interest is observed to antidiabetic biguanide metformin
as candidate drug for cancer chemoprevention. The analysis of the available data have …

Targeting cancer stem‐like cells in glioblastoma and colorectal cancer through metabolic pathways

UD Kahlert, SM Mooney, M Natsumeda… - … Journal of Cancer, 2017 - Wiley Online Library
Cancer stem‐like cells (CSCs) are thought to be the main cause of tumor occurrence,
progression and therapeutic resistance. Strong research efforts in the last decade have led …

Biguanides drugs: past success stories and promising future for drug discovery

O Grytsai, I Myrgorodska, S Rocchi, C Ronco… - European Journal of …, 2021 - Elsevier
Biguanides have attracted much attention a century ago and showed resurgent interest in
recent years after a long period of dormancy. They constitute an important class of …

Combining naringenin and metformin with doxorubicin enhances anticancer activity against triple-negative breast cancer in vitro and in vivo

B Pateliya, V Burade, S Goswami - European journal of pharmacology, 2021 - Elsevier
Triple-negative breast cancer (TNBC) grows fast and represents poor prognosis and
management. This work is aimed to determine the effect of concomitant use of naringenin …