Neurological monogenic loss-of-function diseases are hereditary disorders resulting from
gene mutations that decrease or abolish the normal function of the encoded protein. These …

Organoids are self-organized, three-dimensional structures derived from stem cells that can
mimic the structure and physiology of human organs. Patient-specific induced pluripotent …

In this manuscript, we introduced a French EOAD patient in Korea who carried the presenilin-
1 (PSEN1) Glu318Gly mutations with four possible risk variants, including sortilin-related …

Cytoplasmic mislocalization and aggregation of the RNA-binding protein TDP-43 is a
pathological hallmark of the motor neuron (MN) disease amyotrophic lateral sclerosis (ALS) …

Frontotemporal dementia (FTD) refers to a group of neurodegenerative disorders that are
characterized by pathology predominantly localized to the frontal and temporal lobes …

This review delves into the groundbreaking impact of induced pluripotent stem cells (iPSCs)
and three-dimensional organoid models in propelling forward neuropathology research …

Immuno-neurology is an emerging therapeutic strategy for dementia and neurodegeneration
designed to address immune surveillance failure in the brain. Microglia, as central nervous …

The sheer complexity of the brain has complicated our ability to understand its cellular
mechanisms in health and disease. Genome-wide association studies have uncovered …

Cytoplasmic mislocalization and aggregation of the RNA-binding protein TDP-43 is a
pathological hallmark of the motor neuron (MN) disease amyotrophic lateral sclerosis (ALS) …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder in which
selective death of motor neurons leads to muscle weakness and paralysis. Most research …