In pathophysiology, reactive oxygen species control diverse cellular phenotypes by
oxidizing biomolecules. Among these, the guanine base in nucleic acids is the most …

The present system of radiation protection assumes that exposure at low doses and/or low
dose-rates leads to health risks linearly related to the dose. They are evaluated by a …

Reactive oxygen species (ROS) are produced continuously throughout the cell as products
of various redox reactions. Yet these products function as important signal messengers …

This review focuses on DNA damage caused by a variety of oxidizing, alkylating, and
nitrating species, and it may play an important role in the pathophysiology of inflammation …

Apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APE1/Ref-1) is a
multifunctional enzyme that is essential for maintaining cellular homeostasis. APE1 is the …

The food and drink manufacturing industry is constantly seeking for alternative sanitation
and disinfection systems that may achieve the same antimicrobial efficiency of conventional …

oxo-7, 8-dihydro-2′-deoxyguanosine (8-oxodG), a major product of DNA oxidation, is a pre-
mutagenic lesion which is prone to mispair, if left unrepaired, with 2′-deoxyadenosine …

Oxidative DNA damage has been linked to inflammation, cancer, and aging. Here, we have
mapped two types of oxidative DNA damage, oxidized guanines produced by hydrogen …

Among all reactive oxygen species (ROS), hydrogen peroxide (H2O2) takes a central role in
regulating plant development and responses to the environment. The diverse role of H2O2 …

Compared with the research on DNA damage, there are fewer studies on RNA damage, and
the damage mechanism remains mostly unknown. Recent studies have shown that RNA is …