The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …

Arrhythmogenic cardiomyopathy is a severe cardiac disorder characterized by lethal
arrhythmias and sudden cardiac death, with currently no effective treatment. Plakophilin 2 …

The nucleus of a cardiomyocyte has been increasingly recognized as a morphologically
distinct and partially independent calcium (Ca2+) signaling microdomain, with its own Ca2+ …

Abstract Plakophilin-2 (PKP2) is a key component of desmosomes, which, when defective, is
known to promote the fibro-fatty infiltration of heart muscle. Less attention has been given to …

Objective Metabolic reprogramming is a main feature of proinflammatory macrophage
polarization, a process that leads to inflammation in dysfunctional adipose tissue. Therefore …

The thick-shell mussel Mytilus coruscus serves as a common sessile intertidal species and
holds economic significance as an aquatic organism. M. coruscus often endure higher …

Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac
disease associated with ventricular arrhythmias and an increased risk of sudden cardiac …

Circular RNAs (circRNAs) are a class of non-coding RNAs with diverse functions, and
previous studies have reported that circRNAs are involved in the growth and development of …

Background Recent evidence has brought the mitochondrial contact sites, in communication
with other organelles, to the centre of interest in cellular metabolism because of their …

Cardio‐cerebrovascular diseases encompass pathological changes in the heart, brain and
vascular system, which pose a great threat to health and well‐being worldwide. Moreover …