Karyopherin-mediated nucleocytoplasmic transport
Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …
The roles of hnRNP A2/B1 in RNA biology and disease
Y Liu, SL Shi - Wiley Interdisciplinary Reviews: RNA, 2021 - Wiley Online Library
The RNA‐binding protein hnRNPA2/B1 is a member of the hnRNPs family and is widely
expressed in various tissues. hnRNPA2/B1 recognizes and binds specific RNA substrates …
expressed in various tissues. hnRNPA2/B1 recognizes and binds specific RNA substrates …
Tau activates microglia via the PQBP1-cGAS-STING pathway to promote brain inflammation
M Jin, H Shiwaku, H Tanaka, T Obita, S Ohuchi… - Nature …, 2021 - nature.com
Brain inflammation generally accompanies and accelerates neurodegeneration. Here we
report a microglial mechanism in which polyglutamine binding protein 1 (PQBP1) senses …
report a microglial mechanism in which polyglutamine binding protein 1 (PQBP1) senses …
Selective sorting of microRNAs into exosomes by phase-separated YBX1 condensates
Exosomes may mediate cell-to-cell communication by transporting various proteins and
nucleic acids to neighboring cells. Some protein and RNA cargoes are significantly enriched …
nucleic acids to neighboring cells. Some protein and RNA cargoes are significantly enriched …
Molecular and cellular mechanisms affected in ALS
L Le Gall, E Anakor, O Connolly… - Journal of personalized …, 2020 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a terminal late-onset condition characterized by the
loss of upper and lower motor neurons. Mutations in more than 30 genes are associated to …
loss of upper and lower motor neurons. Mutations in more than 30 genes are associated to …
[HTML][HTML] Stress granule mediated protein aggregation and underlying gene defects in the FTD-ALS spectrum
Y Baradaran-Heravi, C Van Broeckhoven… - Neurobiology of …, 2020 - Elsevier
Stress granules (SGs) are dynamic membraneless compartments composed out of RNA-
binding proteins (RBPs) and RNA molecules that assemble temporarily to allow the cell to …
binding proteins (RBPs) and RNA molecules that assemble temporarily to allow the cell to …
The role of hnRNPs in frontotemporal dementia and amyotrophic lateral sclerosis
Dysregulated RNA metabolism is emerging as a crucially important mechanism
underpinning the pathogenesis of frontotemporal dementia (FTD) and the clinically …
underpinning the pathogenesis of frontotemporal dementia (FTD) and the clinically …
[HTML][HTML] RNA-binding proteins in amyotrophic lateral sclerosis
M Zhao, JR Kim, R van Bruggen, J Park - Molecules and cells, 2018 - Elsevier
Significant research efforts are ongoing to elucidate the complex molecular mechanisms
underlying amyotrophic lateral sclerosis (ALS), which may in turn pinpoint potential …
underlying amyotrophic lateral sclerosis (ALS), which may in turn pinpoint potential …
Rare deleterious mutations of HNRNP genes result in shared neurodevelopmental disorders
Background With the increasing number of genomic sequencing studies, hundreds of genes
have been implicated in neurodevelopmental disorders (NDDs). The rate of gene discovery …
have been implicated in neurodevelopmental disorders (NDDs). The rate of gene discovery …
Structural insights into TDP-43 and effects of post-translational modifications
Transactive response DNA binding protein (TDP-43) is a key player in neurodegenerative
diseases. In this review, we have gathered and presented structural information on the …
diseases. In this review, we have gathered and presented structural information on the …