The development of new therapies for cancer has led to dramatic improvements in
survivorship. Angiogenesis inhibitors represent one such advancement, revolutionising …

KCEK and KRS conceived the study, delineated the hypotheses, designed the study,
analyzed and interpreted data, and prepared the manuscript; SRR, HKE, ALA, MGF, ML …

Human lung growth starts as a primitive lung bud in early embryonic life and undergoes
several morphological stages which continue into postnatal life. Each stage of lung growth is …

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with a median survival time
from diagnosis of 2–3 years. Although the pathogenic pathways have not been fully …

Exposure of the airways epithelium to environmental insults, including cigarette smoke,
results in increased oxidative stress due to unbalance between oxidants and antioxidants in …

Pulmonary arterial hypertension (PAH) is characterized by dysfunctional angiogenesis
leading to lung vessel obliteration. PAH is widely considered a proangiogenic disease; …

Idiopathic pulmonary fibrosis (IPF) is a disabling disease of the lung parenchyma,
characterized by progressive accumulation of scar tissue and myofibroblast activation after …

Rationale: Basic science research suggests a causal role for endothelial dysfunction in
chronic obstructive pulmonary disease (COPD). Clinical studies examining endothelial …

Blood vessels respond to changes in mechanical load from circulating blood in the form of
shear stress and mechanical strain as the result of heart propulsions by changes in …

Idiopathic pulmonary fibrosis (IPF) can lead to the development of secondary pulmonary
hypertension (PH) and ultimately death. Despite this known association, the precise …