Background Disruption of fundamental biologic processes and associated signaling events
may result in clinically significant alterations in lung development. Objectives We reviewed …

Disruption of the balance between matrix metalloproteinases (MMPs) and their endogenous
inhibitors is considered a key event in the development of pulmonary diseases such as …

Apoptosis plays an essential role in homeostasis and pathogenesis of a variety of human
diseases. Endothelial cells are exposed to various environmental and internal stress and …

Malignant pleural effusions (MPEs) are a significant source of cancer-related morbidity. Over
150,000 patients in the United States suffer from breathlessness and diminished quality of …

Chronic Obstructive Pulmonary Disease (COPD) is a complex disease. Genetic, epigenetic,
and environmental factors are known to contribute to COPD risk and disease progression …

Beyond the major gene BMPR2, several new genes predisposing to PAH have been
identified during the last decade. Recently, preliminary evidence of the involvement of the …

α-1 anti-trypsin (AAT) is the most abundant circulating serine protease inhibitor (serpin) and
an acute phase reactant. Systemic deficiency in AAT (AATD) due to genetic mutations can …

Current therapy of pulmonary arterial hypertension (PAH) is inadequate.
Dehydroepiandrosterone (DHEA) effectively treats experimental pulmonary hypertension in …

We sought to determine whether Dopamine D2 Receptor (D 2 R) agonists inhibit lung tumor
progression and identify subpopulations of lung cancer patients that benefit most from D 2 R …

The predominant role of matrix metalloproteinase 8 in extracellular matrix turnover,
modulation of inflammatory responses and other physiological processes is well …