[HTML][HTML] Role of endothelial dysfunction in cardiovascular diseases: the link between inflammation and hydrogen sulfide

HJ Sun, ZY Wu, XW Nie, JS Bian - Frontiers in pharmacology, 2020 - frontiersin.org
Endothelial cells are important constituents of blood vessels that play critical roles in
cardiovascular homeostasis by regulating blood fluidity and fibrinolysis, vascular tone …

Nrf2–ARE signaling in cellular protection: Mechanism of action and the regulatory mechanisms

P Shaw, A Chattopadhyay - Journal of Cellular Physiology, 2020 - Wiley Online Library
Oxidative stress is the increase in cellular oxidant concentration in comparison to antioxidant
titer. Toxic insults and many other diseased conditions are mediated through the formation of …

The biology of ergothioneine, an antioxidant nutraceutical

I Borodina, LC Kenny, CM McCarthy… - Nutrition Research …, 2020 - cambridge.org
Ergothioneine (ERG) is an unusual thio-histidine betaine amino acid that has potent
antioxidant activities. It is synthesised by a variety of microbes, especially fungi (including in …

[HTML][HTML] Oxidative stress-mediated beta cell death and dysfunction as a target for diabetes management

S Dinić, J Arambašić Jovanović, A Uskoković… - Frontiers in …, 2022 - frontiersin.org
The biggest drawback of a current diabetes therapy is the treatment of the consequences not
the cause of the disease. Regardless of the diabetes type, preservation and recovery of …

NRF2 in cardiovascular diseases: a ray of hope!

R Vashi, BM Patel - Journal of cardiovascular translational research, 2021 - Springer
Heart failure is a worldwide pandemic influencing 26 million individuals worldwide and is
expanding. Imbalanced redox homeostasis in cardiac cells alters the structure and function …

Unveiling the role of inflammation and oxidative stress on age‐related cardiovascular diseases

AJPO de Almeida… - Oxidative medicine …, 2020 - Wiley Online Library
The global population above 60 years has been growing exponentially in the last decades,
which is accompanied by an increase in the prevalence of age‐related chronic diseases …

[HTML][HTML] MiR-27b attenuates mitochondrial oxidative stress and inflammation in endothelial cells

N D'Onofrio, F Prattichizzo, E Martino, C Anastasio… - Redox Biology, 2023 - Elsevier
MiR-27b is highly expressed in endothelial cells (EC) but its function in this context is poorly
characterized. This study aims to investigate the effect of miR-27b on inflammatory …

[HTML][HTML] Role of oxidative stress and Nrf2/KEAP1 signaling in colorectal cancer: mechanisms and therapeutic perspectives with phytochemicals

DY Lee, MY Song, EH Kim - Antioxidants, 2021 - mdpi.com
Colorectal cancer still has a high incidence and mortality rate, according to a report from the
American Cancer Society. Colorectal cancer has a high prevalence in patients with …

[HTML][HTML] Natural Nrf2 inhibitors: a review of their potential for cancer treatment

J Zhang, HX Xu, JQ Zhu, YX Dou… - International Journal of …, 2023 - ncbi.nlm.nih.gov
Nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that regulates redox
homeostasis, plays a pivotal role in several cellular processes such as cell proliferation and …

Betanin as a multipath oxidative stress and inflammation modulator: A beetroot pigment with protective effects on cardiovascular disease pathogenesis

DVT Silva, DS Baiao, VF Ferreira… - Critical Reviews in …, 2021 - Taylor & Francis
Oxidative stress is a common physiopathological condition enrolled in risk factors for
cardiovascular diseases. Individuals in such a redox imbalance status present endothelial …