Insulin resistance (IR) in skeletal muscle is a key defect mediating the link between obesity
and type 2 33 diabetes, a disease that typically affects people in later life. Sarcopenia (age …

Advancing age is associated with progressive declines in physiological function that lead to
overt chronic disease, frailty, and eventual mortality. Importantly, age-related physiological …

Metabolic diseases are often characterized by circadian misalignment in different tissues,
yet how altered coordination and communication among tissue clocks relate to specific …

Skeletal muscle possesses dramatic metabolic plasticity that allows for the rapid adaptation
in cellular energy transduction to meet the demands of the organism. Obesity elicits changes …

Conditions and comorbidities of obesity mirror those of ageing and age‐related diseases.
Obesity and ageing share a similar spectrum of phenotypes such as compromised genomic …

Metabolic syndrome (MS) is a condition that includes obesity, insulin resistance,
dyslipidemias among other, abnormalities that favors type 2 Diabetes Mellitus (T2DM) and …

Skeletal muscle atrophy is a pathological condition mainly characterized by a loss of
muscular mass and the contractile capacity of the skeletal muscle as a consequence of …

The ubiquitin–proteasome system (UPS) is the main regulatory mechanism of protein
degradation in skeletal muscle. The ubiquitin-ligase enzymes (E3s) have a central role in …

Comparing energy metabolism in human skeletal muscle and primary skeletal muscle cells
in obesity, while focusing on glucose and fatty acid metabolism, shows many common …

Background Recent studies showed a link between a high fat diet (HFD)-induced obesity
and lipid accumulation in non-adipose tissues, such as skeletal muscle and liver, and insulin …