Anthocyanins: A comprehensive review of their chemical properties and health effects on cardiovascular and neurodegenerative diseases
Anthocyanins are a class of water-soluble flavonoids widely present in fruits and vegetables.
Dietary sources of anthocyanins include red and purple berries, grapes, apples, plums …
Dietary sources of anthocyanins include red and purple berries, grapes, apples, plums …
Metabolic implications of oxidative stress and inflammatory process in SARS-CoV-2 pathogenesis: therapeutic potential of natural antioxidants
GE Forcados, A Muhammad, OO Oladipo… - Frontiers in Cellular …, 2021 - frontiersin.org
COVID-19 is a zoonotic disease with devastating economic and public health impacts
globally. Being a novel disease, current research is focused on a clearer understanding of …
globally. Being a novel disease, current research is focused on a clearer understanding of …
Nicotinamide mononucleotide: a promising molecule for therapy of diverse diseases by targeting NAD+ metabolism
W Hong, F Mo, Z Zhang, M Huang… - Frontiers in cell and …, 2020 - frontiersin.org
NAD+, a co-enzyme involved in a great deal of biochemical reactions, has been found to be
a network node of diverse biological processes. In mammalian cells, NAD+ is synthetized …
a network node of diverse biological processes. In mammalian cells, NAD+ is synthetized …
Functional polarization of neuroglia: implications in neuroinflammation and neurological disorders
Recent neuroscience research has established the adult brain as a dynamic organ having a
unique ability to undergo changes with time. Neuroglia, especially microglia and astrocytes …
unique ability to undergo changes with time. Neuroglia, especially microglia and astrocytes …
The role of type 2 diabetes in neurodegeneration
A growing body of evidence links type-2 diabetes (T2D) with dementia and
neurodegenerative diseases such as Alzheimer's disease (AD). AD is the most common …
neurodegenerative diseases such as Alzheimer's disease (AD). AD is the most common …
Vanillic acid, a bioactive phenolic compound, counteracts LPS-induced neurotoxicity by regulating c-Jun N-terminal kinase in mouse brain
The receptor for advanced glycation end products (RAGE), a pattern recognition receptor
signaling event, has been associated with several human illnesses, including …
signaling event, has been associated with several human illnesses, including …
Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease
Z Yao, W Yang, Z Gao, P Jia - Neuroscience letters, 2017 - Elsevier
Amyloid-β (Aβ) oligomers have been accepted as major neurotoxic agents in the therapy of
Alzheimer's disease (AD). It has been shown that the activity of nicotinamide adenine …
Alzheimer's disease (AD). It has been shown that the activity of nicotinamide adenine …
Strategies for the selective regulation of kinases with allosteric modulators: exploiting exclusive structural features
Z Fang, C Grütter, D Rauh - ACS chemical biology, 2013 - ACS Publications
The modulation of kinase function has become an important goal in modern drug discovery
and chemical biology research. In cancer-targeted therapies, kinase inhibitors have been …
and chemical biology research. In cancer-targeted therapies, kinase inhibitors have been …
Astrocytic metabolic and inflammatory changes as a function of age
T Jiang, E Cadenas - Aging cell, 2014 - Wiley Online Library
This study examines age‐dependent metabolic‐inflammatory axis in primary astrocytes
isolated from brain cortices of 7‐, 13‐, and 18‐month‐old Sprague–Dawley male rats …
isolated from brain cortices of 7‐, 13‐, and 18‐month‐old Sprague–Dawley male rats …
Glycine, the smallest amino acid, confers neuroprotection against d-galactose-induced neurodegeneration and memory impairment by regulating c-Jun N-terminal …
Background Glycine is the smallest nonessential amino acid and has previously
unrecognized neurotherapeutic effects. In this study, we examined the mechanism …
unrecognized neurotherapeutic effects. In this study, we examined the mechanism …