Abstract Background Over 100 million Americans are living with chronic pain, and pain is the
most common reason that patients seek medical attention. Despite the prevalence of pain …

Long‐term opioid management for chronic noncancer pain - Noble, M - 2010 | Cochrane
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Aims Our study sought to assess the prevalence of and risk factors for opioid drug
dependence among out‐patients on long‐term opioid therapy in a large health‐care system …

Design. This is a structured evidence-based review of all available studies on the
development of abuse/addiction and aberrant drug-related behaviors (ADRBs) in chronic …

OBJECTIVE: To assess the prevalence, treatment and impact of chronic pain in Canada.
METHODS: A stratified random sample of 2012 adult Canadians (weighted by sex, age and …

We conducted an analytic review of the clinical scientific literature bearing on the use of
opioids for treatment of chronic non-cancer pain. There is substantial, albeit not definitive …

Opioid therapy for chronic pain has been popularized over the past few decades, and a
concern has arisen that the analgesic efficacy of opioids is not always maintained over …

Background: Opioid abuse has continued to increase at an alarming rate since our last
opioid guidelines were published in 2005. Available evidence suggests a continued wide …

Opioid therapy for chronic noncancer pain (CNCP) is controversial due to concerns
regarding long-term efficacy and adverse events (including addiction). We systematically …

Background: Opioid abuse has increased at an alarming rate. However, available evidence
suggests a wide variance in the use of opioids, as documented by different medical …