[HTML][HTML] The neurovascular unit coming of age: a journey through neurovascular coupling in health and disease
C Iadecola - Neuron, 2017 - cell.com
The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke Progress
Review Group meeting of the National Institute of Neurological Disorders and Stroke …
Review Group meeting of the National Institute of Neurological Disorders and Stroke …
Neuronal regulation of the blood–brain barrier and neurovascular coupling
L Kaplan, BW Chow, C Gu - Nature Reviews Neuroscience, 2020 - nature.com
To continuously process neural activity underlying sensation, movement and cognition, the
CNS requires a homeostatic microenvironment that is not only enriched in nutrients to meet …
CNS requires a homeostatic microenvironment that is not only enriched in nutrients to meet …
Brain capillary pericytes exert a substantial but slow influence on blood flow
The majority of the brain's vasculature is composed of intricate capillary networks lined by
capillary pericytes. However, it remains unclear whether capillary pericytes influence blood …
capillary pericytes. However, it remains unclear whether capillary pericytes influence blood …
[HTML][HTML] High-speed three-dimensional photoacoustic computed tomography for preclinical research and clinical translation
Photoacoustic computed tomography (PACT) has generated increasing interest for uses in
preclinical research and clinical translation. However, the imaging depth, speed, and quality …
preclinical research and clinical translation. However, the imaging depth, speed, and quality …
[HTML][HTML] Neurovascular coupling and oxygenation are decreased in hippocampus compared to neocortex because of microvascular differences
The hippocampus is essential for spatial and episodic memory but is damaged early in
Alzheimer's disease and is very sensitive to hypoxia. Understanding how it regulates its …
Alzheimer's disease and is very sensitive to hypoxia. Understanding how it regulates its …
[HTML][HTML] Neuronal stimulation triggers neuronal glycolysis and not lactate uptake
CM Díaz-García, R Mongeon, C Lahmann, D Koveal… - Cell metabolism, 2017 - cell.com
Proper brain function requires a substantial energy supply, up to 20% of whole-body energy
in humans, and brain activation produces large dynamic variations in energy demand. While …
in humans, and brain activation produces large dynamic variations in energy demand. While …
Defining physiological normoxia for improved translation of cell physiology to animal models and humans
TP Keeley, GE Mann - Physiological reviews, 2019 - journals.physiology.org
The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …
[HTML][HTML] Pericyte remodeling is deficient in the aged brain and contributes to impaired capillary flow and structure
Deterioration of brain capillary flow and architecture is a hallmark of aging and dementia. It
remains unclear how loss of brain pericytes in these conditions contributes to capillary …
remains unclear how loss of brain pericytes in these conditions contributes to capillary …
The capillary bed offers the largest hemodynamic resistance to the cortical blood supply
IG Gould, P Tsai, D Kleinfeld… - Journal of Cerebral …, 2017 - journals.sagepub.com
The cortical angioarchitecture is a key factor in controlling cerebral blood flow and oxygen
metabolism. Difficulties in imaging the complex microanatomy of the cortex have so far …
metabolism. Difficulties in imaging the complex microanatomy of the cortex have so far …
[HTML][HTML] Brain microvasculature has a common topology with local differences in geometry that match metabolic load
The microvasculature underlies the supply networks that support neuronal activity within
heterogeneous brain regions. What are common versus heterogeneous aspects of the …
heterogeneous brain regions. What are common versus heterogeneous aspects of the …