The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke Progress
Review Group meeting of the National Institute of Neurological Disorders and Stroke …

To continuously process neural activity underlying sensation, movement and cognition, the
CNS requires a homeostatic microenvironment that is not only enriched in nutrients to meet …

The majority of the brain's vasculature is composed of intricate capillary networks lined by
capillary pericytes. However, it remains unclear whether capillary pericytes influence blood …

Photoacoustic computed tomography (PACT) has generated increasing interest for uses in
preclinical research and clinical translation. However, the imaging depth, speed, and quality …

The hippocampus is essential for spatial and episodic memory but is damaged early in
Alzheimer's disease and is very sensitive to hypoxia. Understanding how it regulates its …

Proper brain function requires a substantial energy supply, up to 20% of whole-body energy
in humans, and brain activation produces large dynamic variations in energy demand. While …

The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …

Deterioration of brain capillary flow and architecture is a hallmark of aging and dementia. It
remains unclear how loss of brain pericytes in these conditions contributes to capillary …

The cortical angioarchitecture is a key factor in controlling cerebral blood flow and oxygen
metabolism. Difficulties in imaging the complex microanatomy of the cortex have so far …

The microvasculature underlies the supply networks that support neuronal activity within
heterogeneous brain regions. What are common versus heterogeneous aspects of the …