A comprehensive atlas of E3 ubiquitin ligase mutations in neurological disorders
AJ George, YC Hoffiz, AJ Charles, Y Zhu… - Frontiers in …, 2018 - frontiersin.org
Protein ubiquitination is a posttranslational modification that plays an integral part in
mediating diverse cellular functions. The process of protein ubiquitination requires an …
mediating diverse cellular functions. The process of protein ubiquitination requires an …
Exploring the role of ubiquitin–proteasome system in Parkinson's disease
Over the last decade, researchers have discovered that a group of apparently unrelated
neurodegenerative disorders, such as Parkinson's disease, have remarkable cellular and …
neurodegenerative disorders, such as Parkinson's disease, have remarkable cellular and …
Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer's-like pathology in mouse and fly APP overexpression models
The proteasome has key roles in neuronal proteostasis, including the removal of misfolded
and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity …
and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity …
De novo disruption of the proteasome regulatory subunit PSMD12 causes a syndromic neurodevelopmental disorder
Degradation of proteins by the ubiquitin-proteasome system (UPS) is an essential biological
process in the development of eukaryotic organisms. Dysregulation of this mechanism leads …
process in the development of eukaryotic organisms. Dysregulation of this mechanism leads …
The ubiquitin-proteasome system and learning-dependent synaptic plasticity–A 10 year update
Over 25 years ago, a seminal paper demonstrated that the ubiquitin-proteasome system
(UPS) was involved in activity-dependent synaptic plasticity. Interest in this topic began to …
(UPS) was involved in activity-dependent synaptic plasticity. Interest in this topic began to …
Proteolysis, synaptic plasticity and memory
AN Hegde - Neurobiology of learning and memory, 2017 - Elsevier
Protein degradation has many critical functions in the nervous system such as refinement of
synaptic connections during development and synaptic plasticity and memory in the adult …
synaptic connections during development and synaptic plasticity and memory in the adult …
Proteomic analysis reveals sex-specific protein degradation targets in the amygdala during fear memory formation
K Farrell, M Musaus, S Navabpour, K Martin… - Frontiers in Molecular …, 2021 - frontiersin.org
Ubiquitin-proteasome mediated protein degradation has been widely implicated in fear
memory formation in the amygdala. However, to date, the protein targets of the proteasome …
memory formation in the amygdala. However, to date, the protein targets of the proteasome …
PI31 is an adaptor protein for proteasome transport in axons and required for synaptic development
Protein degradation by the ubiquitin-proteasome system is critical for neuronal function.
Neurons utilize microtubule-dependent molecular motors to allocate proteasomes to …
Neurons utilize microtubule-dependent molecular motors to allocate proteasomes to …
Reconsolidation and the regulation of plasticity: moving beyond memory
RP Bonin, Y De Koninck - Trends in neurosciences, 2015 - cell.com
Memory reconsolidation is a protein synthesis-dependent process that preserves, in some
form, memories that have been destabilized through recall. Reconsolidation is a nearly …
form, memories that have been destabilized through recall. Reconsolidation is a nearly …
Misframed ubiquitin and impaired protein quality control: an early event in Alzheimer's disease
RJ Gentier, FW Van Leeuwen - Frontiers in molecular neuroscience, 2015 - frontiersin.org
Amyloid β (Aβ) plaque formation is a prominent cellular hallmark of Alzheimer's disease
(AD). To date, immunization trials in AD patients have not been effective in terms of curing or …
(AD). To date, immunization trials in AD patients have not been effective in terms of curing or …