Protein ubiquitination is a posttranslational modification that plays an integral part in
mediating diverse cellular functions. The process of protein ubiquitination requires an …

Over the last decade, researchers have discovered that a group of apparently unrelated
neurodegenerative disorders, such as Parkinson's disease, have remarkable cellular and …

The proteasome has key roles in neuronal proteostasis, including the removal of misfolded
and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity …

Degradation of proteins by the ubiquitin-proteasome system (UPS) is an essential biological
process in the development of eukaryotic organisms. Dysregulation of this mechanism leads …

Over 25 years ago, a seminal paper demonstrated that the ubiquitin-proteasome system
(UPS) was involved in activity-dependent synaptic plasticity. Interest in this topic began to …

Protein degradation has many critical functions in the nervous system such as refinement of
synaptic connections during development and synaptic plasticity and memory in the adult …

Ubiquitin-proteasome mediated protein degradation has been widely implicated in fear
memory formation in the amygdala. However, to date, the protein targets of the proteasome …

Protein degradation by the ubiquitin-proteasome system is critical for neuronal function.
Neurons utilize microtubule-dependent molecular motors to allocate proteasomes to …

Memory reconsolidation is a protein synthesis-dependent process that preserves, in some
form, memories that have been destabilized through recall. Reconsolidation is a nearly …

Amyloid β (Aβ) plaque formation is a prominent cellular hallmark of Alzheimer's disease
(AD). To date, immunization trials in AD patients have not been effective in terms of curing or …