Transcriptional control of effector and memory CD8+ T cell differentiation
During an infection, T cells can differentiate into multiple types of effector and memory T
cells, which help to mediate pathogen clearance and provide long-term protective immunity …
cells, which help to mediate pathogen clearance and provide long-term protective immunity …
Paths to stemness: building the ultimate antitumour T cell
Stem cells are defined by the ability to self-renew and to generate differentiated progeny,
qualities that are maintained by evolutionarily conserved pathways that can lead to cancer …
qualities that are maintained by evolutionarily conserved pathways that can lead to cancer …
Nanoparticle‐enhanced radiotherapy to trigger robust cancer immunotherapy
External radiotherapy is extensively used in clinic to destruct tumors by locally applied
ionizing‐radiation beams. However, the efficacy of radiotherapy is usually limited by tumor …
ionizing‐radiation beams. However, the efficacy of radiotherapy is usually limited by tumor …
Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer
Local environmental factors influence CD8+ T cell priming in lymph nodes (LNs). Here, we
sought to understand how factors unique to the tumor-draining mediastinal LN (mLN) impact …
sought to understand how factors unique to the tumor-draining mediastinal LN (mLN) impact …
Near-infrared-triggered photodynamic therapy with multitasking upconversion nanoparticles in combination with checkpoint blockade for immunotherapy of colorectal …
While immunotherapy has become a highly promising paradigm for cancer treatment in
recent years, it has long been recognized that photodynamic therapy (PDT) has the ability to …
recent years, it has long been recognized that photodynamic therapy (PDT) has the ability to …
A hepatocellular carcinoma targeting nanostrategy with hypoxia-ameliorating and photothermal abilities that, combined with immunotherapy, inhibits metastasis and …
T Zhou, X Liang, P Wang, Y Hu, Y Qi, Y Jin, Y Du… - ACS …, 2020 - ACS Publications
Hepatocellular carcinoma (HCC) is a common and highly malignant tumor that is prone to
recurrence and metastasis and has no effective treatment. Unsurprisingly, its prognosis is …
recurrence and metastasis and has no effective treatment. Unsurprisingly, its prognosis is …
[PDF][PDF] Inflammation directs memory precursor and short-lived effector CD8+ T cell fates via the graded expression of T-bet transcription factor
As acute infections resolve, effector CD8+ T cells differentiate into interleukin-7 receptor lo
(IL-7R lo) short-lived effector cells (SLECs) and IL-7R hi memory precursor effector cells …
(IL-7R lo) short-lived effector cells (SLECs) and IL-7R hi memory precursor effector cells …
Disparate Individual Fates Compose Robust CD8+ T Cell Immunity
A core feature of protective T cell responses to infection is the robust expansion and
diversification of naïve antigen-specific T cell populations into short-lived effector and long …
diversification of naïve antigen-specific T cell populations into short-lived effector and long …
Clonal expansion of innate and adaptive lymphocytes
NM Adams, S Grassmann, JC Sun - Nature Reviews Immunology, 2020 - nature.com
One of the hallmarks of the vertebrate adaptive immune system is the prolific expansion of
individual cell clones that encounter their cognate antigen. More recently, however, there is …
individual cell clones that encounter their cognate antigen. More recently, however, there is …
Heterogeneous Differentiation Patterns of Individual CD8+ T Cells
Upon infection, antigen-specific CD8+ T lymphocyte responses display a highly
reproducible pattern of expansion and contraction that is thought to reflect a uniform …
reproducible pattern of expansion and contraction that is thought to reflect a uniform …