Intercellular calcium (Ca2+) waves (ICWs) represent the propagation of increases in
intracellular Ca2+ through a syncytium of cells and appear to be a fundamental mechanism …

Cxs (connexins), the protein subunits forming gap junction intercellular communication
channels, are transported to the plasma membrane after oligomerizing into hexameric …

Secretion of pulmonary surfactant in the alveoli of the lungs is essential to maintain lung
function. Stretching of alveoli during lung inflation is the main trigger for surfactant secretion …

Gap junctions and connexins are present in the immune system. In haematopoiesis,
connexin 43, the most widely distributed gap junction protein, appears to be a key player in …

Background Single nucleotide polymorphisms in the human gene for the receptor for
advanced glycation end-products (RAGE) are associated with an increased incidence of …

Second messenger signaling between endothelial cells (ECs) and vascular smooth muscle
cells (VSMCs) is poorly understood, but intracellular Ca2+ concentrations ([Ca2+] i) in the 2 …

The distal lung provides an intricate structure for gas exchange in mammalian lungs.
Efficient gas exchange depends on the functional integrity of lung alveoli. The cells in the …

Gap junctions are key components underpinning multicellularity. They provide cell to cell
channel pathways that enable direct intercellular communication and cellular coordination in …

Many essential physiological processes are controlled by calcium. To ensure reliability and
specificity, calcium signals are highly organized in time and space in the form of oscillations …

Background Lung cancer is a leading cause of cancer morbidity. To improve an
understanding of molecular causes of disease a transgenic mouse model was investigated …