[HTML][HTML] Acquired HIV drug resistance mutations on first-line antiretroviral therapy in Southern Africa: Systematic review and Bayesian evidence synthesis
A Hauser, F Goldstein, ML Reichmuth… - Journal of clinical …, 2022 - Elsevier
Objective: To estimate the prevalence of NRTI and NNRTI drug resistance mutations in
patients failing NNRTI-based ART in Southern Africa. Study design: We conducted a …
patients failing NNRTI-based ART in Southern Africa. Study design: We conducted a …
PANGEA-HIV 2: phylogenetics and networks for generalised epidemics in Africa
L Abeler-Dörner, MK Grabowski… - Current Opinion in …, 2019 - journals.lww.com
Combining phylogenetics, phylodynamics and epidemiology will allow PANGEA to highlight
where prevention efforts should be focussed to reduce the HIV epidemic most effectively. To …
where prevention efforts should be focussed to reduce the HIV epidemic most effectively. To …
[HTML][HTML] Differential effects of antiretroviral treatment on immunity and gut microbiome composition in people living with HIV in rural versus urban Zimbabwe
AS Burkhart Colorado, A Lazzaro, CP Neff… - Microbiome, 2024 - Springer
Background The widespread availability of antiretroviral therapy (ART) has dramatically
reduced mortality and improved life expectancy for people living with HIV (PLWH). However …
reduced mortality and improved life expectancy for people living with HIV (PLWH). However …
[HTML][HTML] Occult HIV-1 drug resistance to thymidine analogues following failure of first-line tenofovir combined with a cytosine analogue and nevirapine or efavirenz in …
J Gregson, P Kaleebu, VC Marconi… - The Lancet infectious …, 2017 - thelancet.com
Background HIV-1 drug resistance to older thymidine analogue nucleoside reverse
transcriptase inhibitor drugs has been identified in sub-Saharan Africa in patients with …
transcriptase inhibitor drugs has been identified in sub-Saharan Africa in patients with …
[HTML][HTML] Simplifying switch to second-line antiretroviral therapy in sub Saharan Africa: predicted effect of using a single viral load to define efavirenz-based first-line …
A Shroufi, G Van Cutsem, V Cambiano… - Aids, 2019 - journals.lww.com
Background: Many individuals failing first-line antiretroviral therapy (ART) in sub-Saharan
Africa never initiate second-line ART or do so after significant delay. For people on ART with …
Africa never initiate second-line ART or do so after significant delay. For people on ART with …
[HTML][HTML] Adoption of routine virologic testing and predictors of virologic failure among HIV-infected children on antiretroviral treatment in western Kenya
J Kadima, E Patterson, M Mburu, C Blat, M Nyanduko… - PloS one, 2018 - journals.plos.org
Background Access to routine virologic monitoring, critical to ensuring treatment success,
remains limited in low-and middle-income countries. We report on implementation of routine …
remains limited in low-and middle-income countries. We report on implementation of routine …
[HTML][HTML] High level of HIV-1 drug resistance mutations in patients with unsuppressed viral loads in rural northern South Africa
EM Etta, L Mavhandu, C Manhaeve… - AIDS research and …, 2017 - Springer
Background Combination antiretroviral therapy (cART) has significantly reduced HIV
morbidity and mortality in both developed and developing countries. However, the …
morbidity and mortality in both developed and developing countries. However, the …
Incidence and predictors of treatment failure among children receiving first-line antiretroviral treatment in general hospitals of two zones, Tigray, Ethiopia, 2019
M Sibhat, M Kassa, H Gebrehiwot - Pediatric health, medicine and …, 2020 - Taylor & Francis
Background Despite many efforts undertaken to control the human immunodeficiency virus
epidemic, it remains to be the major global public health challenge. With expanding access …
epidemic, it remains to be the major global public health challenge. With expanding access …
[HTML][HTML] Antiretroviral treatment failure among HIV-positive adults taking first-line therapy and associated risk factors at Adigrat General hospital, Adigart, Ethiopia 2019 …
DG Demsie, AT Bantie, MD Allene, NM Alema… - International Journal of …, 2020 - Elsevier
Abstract Background Human Immunodeficiency Virus (HIV) is a major public health problem
globally. Highly active antiretroviral therapy (HAART) has led to profound reduction in the …
globally. Highly active antiretroviral therapy (HAART) has led to profound reduction in the …
[HTML][HTML] Drug resistance mutations against protease, reverse transcriptase and integrase inhibitors in people living with HIV-1 receiving boosted protease inhibitors in …
The South African national combination antiretroviral therapy (cART) roll-out program started
in 2006, with over 4.4 million people accessing treatment since it was first introduced. HIV-1 …
in 2006, with over 4.4 million people accessing treatment since it was first introduced. HIV-1 …