The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …

Pioneering studies performed over the past few decades demonstrate links between
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …

INTRODUCTION Mitochondria are essential organelles whose form and function are
inextricably linked. Balanced fusion and fission events shape mitochondria to meet …

Reversible acetylation was initially described as an epigenetic mechanism regulating DNA
accessibility. Since then, this process has emerged as a controller of histone and nonhistone …

Dynamic packaging of DNA into strings of nucleosomes is a major mechanism whereby
eukaryotic cells regulate gene expression. Intricate control of nucleosomal structure and …

Progenitor cells differentiate into specialized cell types through coordinated expression of
lineage-specific genes and modification of complex chromatin configurations. We …

During the processes leading to adverse cardiac remodeling and heart failure,
cardiomyocytes react to neurohumoral stimuli and biomechanical stress by activating …

Cell-type-specific gene expression is physiologically modulated by the binding of
transcription factors to genomic enhancer sequences, to which chromatin modifiers such as …

Macrophages, a key cellular component of inflammation, become functionally polarized in a
signal-and context-specific manner. Th2 cytokines such as interleukin 4 (IL-4) polarize …

Brown adipose tissue is a thermogenic organ that dissipates chemical energy as heat to
protect animals against hypothermia and to counteract metabolic disease. However, the …